Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | EEF2K | O00418 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.40 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888324 | 0.92 | KDM4E (0.45) | KDM4ECYP19A1EEF2KARSIGMAR1 | |
| SCHEMBL3676809 | 0.87 | KDM4E (0.55) | KDM4ECYP19A1EEF2KARSIGMAR1 | |
| SCHEMBL3671443 | 0.87 | KDM4E (0.55) | KDM4ECYP19A1EEF2KARSIGMAR1 | |
| SCHEMBL29608352 | 0.87 | KDM4E (0.55) | KDM4ECYP19A1EEF2KARSIGMAR1 | |
| SCHEMBL3671445 | 0.87 | KDM4E (0.55) | KDM4ECYP19A1EEF2KARSIGMAR1 | |
| SCHEMBL8919310 | 0.86 | CYP19A1 (0.46) | KDM4ECYP19A1ARKIF11S100A4 | |
| SCHEMBL8890205 | 0.86 | THRB (0.46) | KDM4ETRPM5ALDH1A1ALDH2HPGD | |
| SCHEMBL8887946 | 0.83 | TRPM4 (0.46) | KDM4ECYP19A1TRPM5TRPM4 | |
| SCHEMBL8886219 | 0.81 | LMNA (0.41) | KDM4ECYP19A1ARALDH1A1GAA | |
| SCHEMBL6001645 | 0.81 | RAB9A (0.49) | KDM4EEEF2KALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2720989-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF SCHIZOPHRENIA | H. Lundbeck A/S (DK) | 2014-04-23 | — | — | EP | disclosed |
| WO-2012176066-A1 | DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF SCHIZOPHRENIA | H. LUNDBECK A/S (DK) | 2012-12-27 | — | — | WO | disclosed |
| EP-1853574-A1 | PROCESS FOR MAKING TRANS-1-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3,3-DIMETHYLPIPERAZINE | H. Lundbeck A/S (DK) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006086984-A1 | PROCESS FOR MAKING TRANS-1-((1R, 3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3, 3-DIMETHYLPIPERAZINE | H. LUNDBECK A/S (DK) | 2006-08-24 | — | — | WO | disclosed |
| US-5643784-A | TREATMENT OF ANXIETY, DEPRESSION, SLEEPING DISORDERS, SCHIZOPHRENIA AND MIGRAINE | H, LUNDBECK A/S (DK) | 1997-07-01 | — | — | US | disclosed |
| EP-0560868-B1 | INDAN DERIVATIVES | LUNDBECK & CO AS H (DK) | 1995-04-19 | — | — | EP | disclosed |
| EP-0560868-A1 | INDAN DERIVATIVES. | LUNDBECK & CO AS H (DK) | 1993-09-22 | — | — | EP | disclosed |
| WO-1992010192-A1 | INDAN DERIVATIVES | H. LUNDBECK A/S (DK) | 1992-06-25 | — | — | WO | disclosed |