Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | EEF2K | O00418 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.40 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671445 | 1.00 | KDM4E (0.55) | KDM4ECYP19A1EEF2KARALDH1A1 | |
| SCHEMBL3676809 | 1.00 | KDM4E (0.55) | KDM4ECYP19A1EEF2KARALDH1A1 | |
| SCHEMBL29608352 | 1.00 | KDM4E (0.55) | KDM4ECYP19A1EEF2KARALDH1A1 | |
| SCHEMBL5612911 | 0.87 | KDM4E (0.55) | KDM4ECYP19A1EEF2KARALDH1A1 | |
| SCHEMBL5709390 | 0.86 | THRB (0.49) | KDM4ECYP19A1ALDH1A1ALDH2LMNA | |
| SCHEMBL5709373 | 0.81 | SLC6A2 (0.39) | KDM4ECYP19A1ARHTTLMNA | |
| SCHEMBL14244628 | 0.81 | HTR1A (0.39) | KDM4ECYP19A1ARALDH1A1SIGMAR1 | |
| SCHEMBL29606711 | 0.81 | HTR1A (0.39) | KDM4ECYP19A1ARALDH1A1SIGMAR1 | |
| SCHEMBL14244391 | 0.81 | HTR1A (0.39) | KDM4ECYP19A1ARALDH1A1SIGMAR1 | |
| SCHEMBL6001645 | 0.81 | RAB9A (0.49) | KDM4EEEF2KALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2639216-B1 | HALOGENATED INDENONES AND METHOD FOR PRODUCING OPTICALLY ACTIVE INDANONES OR OPTICALLY ACTIVE INDANOLS BY USING SAME | KANEKA CORP (JP) | 2018-07-11 | — | — | EP | disclosed |
| US-8569499-B2 | Process for making trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine | H. LUNDBECK A/S (DK) | 2013-10-29 | — | — | US | disclosed |
| US-8569499-B2 | Process for making trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine | H. LUNDBECK A/S (DK) | 2013-10-29 | — | — | US | disclosed |
| US-8569499-B2 | Process for making trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine | H. LUNDBECK A/S (DK) | 2013-10-29 | — | — | US | disclosed |
| EP-2639216-A1 | HALOGENATED INDENONES AND METHOD FOR PRODUCING OPTICALLY ACTIVE INDANONES OR OPTICALLY ACTIVE INDANOLS BY USING SAME | Kaneka Corporation (JP) | 2013-09-18 | — | — | EP | disclosed |
| CN-101137632-B | Process for the preparation of trans-1- ((1R,3S) -6-chloro-3-phenylindan-1-yl) -3, 3-dimethylpiperazine | LUNDBECK & CO AS H | 2013-06-19 | — | — | CN | disclosed |
| US-20100069676-A1 | PROCESS FOR MAKING TRANS-1-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3,3-DIMETHYLPIPERAZINE | H. LUNDBECK A/S (DK) | 2010-03-18 | — | — | US | disclosed |
| US-20100069676-A1 | PROCESS FOR MAKING TRANS-1-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3,3-DIMETHYLPIPERAZINE | H. LUNDBECK A/S (DK) | 2010-03-18 | — | — | US | disclosed |
| US-20100069676-A1 | PROCESS FOR MAKING TRANS-1-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3,3-DIMETHYLPIPERAZINE | H. LUNDBECK A/S (DK) | 2010-03-18 | — | — | US | disclosed |
| US-20080153847-A1 | 2,2-Dimethylpiperazine derivative is reacted with 6-chloro-3-phenyl-indan-1-ol or 6-chloro-3-phenylindan-1-one; salt formation, precipitation, resolution, crystallization, amination, immobilization, catalysis; schizophrenia, psychoses, drug abuse, alcoholism; anxiolytic and antidepressants | H. LUNDBECK A/S (DK) | 2008-06-26 | — | — | US | disclosed |
| US-20080153847-A1 | 2,2-Dimethylpiperazine derivative is reacted with 6-chloro-3-phenyl-indan-1-ol or 6-chloro-3-phenylindan-1-one; salt formation, precipitation, resolution, crystallization, amination, immobilization, catalysis; schizophrenia, psychoses, drug abuse, alcoholism; anxiolytic and antidepressants | H. LUNDBECK A/S (DK) | 2008-06-26 | — | — | US | disclosed |
| US-20080153847-A1 | 2,2-Dimethylpiperazine derivative is reacted with 6-chloro-3-phenyl-indan-1-ol or 6-chloro-3-phenylindan-1-one; salt formation, precipitation, resolution, crystallization, amination, immobilization, catalysis; schizophrenia, psychoses, drug abuse, alcoholism; anxiolytic and antidepressants | H. LUNDBECK A/S (DK) | 2008-06-26 | — | — | US | disclosed |
| CN-101137632-A | Process for the preparation of trans-1- ((1R,3S) -6-chloro-3-phenylindan-1-yl) -3, 3-dimethylpiperazine | LUNDBECK & CO AS H (DK) | 2008-03-05 | — | — | CN | disclosed |
| EP-1853574-A1 | PROCESS FOR MAKING TRANS-1-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3,3-DIMETHYLPIPERAZINE | H. Lundbeck A/S (DK) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006086984-A1 | PROCESS FOR MAKING TRANS-1-((1R, 3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3, 3-DIMETHYLPIPERAZINE | H. LUNDBECK A/S (DK) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069676-A1 | PROCESS FOR MAKING TRANS-1-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3,3-DIMETHYLPIPERAZINE | CYP4Z1, CYP4F3, CYP1A1 | KDM4E 1119/4885CYP19A1 85/4885EEF2K 2381/4885 |
| US-20080153847-A1 | 2,2-Dimethylpiperazine derivative is reacted with 6-chloro-3-phenyl-indan-1-ol or 6-chloro-3-phenylindan-1-one; salt formation, precipitation, resolution, crystallization, amination, immobilization, catalysis; schizophrenia, psychoses, drug abuse, alcoholism; anxiolytic and antidepressants | ADH1A, ADH1C, ADH5 | KDM4E 1117/4885CYP19A1 660/4885EEF2K 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.