Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578447 | 0.85 | HPGD (0.36) | DRD2SIGMAR1HRH2HRH1 | |
| SCHEMBL5616199 | 0.82 | SIGMAR1 (0.43) | DRD2SIGMAR1SLC18A3DRD3 | |
| SCHEMBL5822828 | 0.79 | DRD2 (0.38) | DRD2SIGMAR1HRH2HRH1SLC18A3 | |
| SCHEMBL4890976 | 0.76 | DRD2 (0.39) | DRD2SIGMAR1HRH2HRH1SLC18A3 | |
| SCHEMBL5578898 | 0.75 | SIGMAR1 (0.36) | SIGMAR1 | |
| SCHEMBL5578564 | 0.73 | DRD2 (0.47) | DRD2SIGMAR1SLC18A3 | |
| SCHEMBL5820469 | 0.73 | DRD2 (0.47) | DRD2SIGMAR1SLC18A3DRD3 | |
| SCHEMBL5579040 | 0.72 | HPGD (0.38) | DRD2SIGMAR1HRH2HRH1 | |
| SCHEMBL5578732 | 0.72 | DRD2 (0.48) | DRD2SIGMAR1SLC18A3 | |
| SCHEMBL5578907 | 0.71 | HPGD (0.35) | DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | disclosed |