Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5616199 | 0.89 | SIGMAR1 (0.43) | DRD2SIGMAR1SLC18A3DRD3ATM | |
| SCHEMBL5579307 | 0.86 | ATM (0.36) | SIGMAR1ATMOPRM1OPRD1OPRK1 | |
| SCHEMBL4761716 | 0.85 | OPRK1 (0.40) | DRD2SIGMAR1SLC18A3S1PR5S1PR1 | |
| SCHEMBL4890976 | 0.82 | DRD2 (0.39) | DRD2SIGMAR1SLC18A3DRD3ATM | |
| SCHEMBL5578564 | 0.81 | DRD2 (0.47) | DRD2SIGMAR1SLC18A3ATM | |
| Trifluoroacetic Acid SCHEMBL4881007 | 0.80 | OPRK1 (0.37) | DRD2SIGMAR1SLC18A3S1PR5S1PR1 | |
| SCHEMBL5820469 | 0.80 | DRD2 (0.47) | DRD2SIGMAR1SLC18A3DRD3ATM | |
| SCHEMBL4886630 | 0.80 | SLC18A3 (0.35) | SIGMAR1SLC18A3S1PR5S1PR1OPRM1 | |
| SCHEMBL5578732 | 0.80 | DRD2 (0.48) | DRD2SIGMAR1SLC18A3ATMHPGD | |
| SCHEMBL5616163 | 0.79 | DRD2 (0.39) | DRD2SIGMAR1SLC18A3S1PR5S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | disclosed |