Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.38 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL29823097 | 0.94 | HPGD (0.40) | HPGDKMT2ASMN1; SMN2PKMCHRNB2 | |
| Trifluoroacetic Acid SCHEMBL4071422 | 0.93 | HTR6 (0.43) | HPGDKMT2ASMN1; SMN2PKMCHRNB2 | |
| Trifluoroacetic Acid SCHEMBL1018462 | 0.93 | HTR6 (0.43) | HPGDKMT2ASMN1; SMN2PKMCHRNB2 | |
| Trifluoroacetic Acid SCHEMBL3963270 | 0.88 | HTR6 (0.43) | KMT2AHTR6L3MBTL3L3MBTL1HRH3 | |
| Trifluoroacetic Acid SCHEMBL21816712 | 0.88 | HRH3 (0.39) | HPGDKMT2ASMN1; SMN2HRH3 | |
| Trifluoroacetic Acid SCHEMBL1546542 | 0.85 | L3MBTL3 (0.39) | HPGDKMT2ASMN1; SMN2PKMCHRNB2 | |
| Trifluoroacetic Acid SCHEMBL7330887 | 0.84 | KMT2A (0.74) | HPGDKMT2ASMN1; SMN2KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL20236674 | 0.84 | PKM (0.36) | HPGDKMT2ASMN1; SMN2PKMCHRNB2 | |
| Trifluoroacetic Acid SCHEMBL17262311 | 0.84 | PKM (0.36) | HPGDKMT2ASMN1; SMN2PKMCHRNB2 | |
| Trifluoroacetic Acid SCHEMBL22587649 | 0.83 | ALDH1A1 (0.46) | HPGDKMT2ASMN1; SMN2PKMHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276509-B2 | Piperidine derivatives and their use as antagonists of tachykinins | GLAXO GROUP LIMITED (GB) | 2007-10-02 | — | — | US | disclosed |
| US-20050096313-A1 | Piperidine derivatives and their use as antagonists of tachykinins | GLAXO GROUP LIMITED (GB) | 2005-05-05 | — | — | US | disclosed |
| EP-1472243-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003066621-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096313-A1 | Piperidine derivatives and their use as antagonists of tachykinins | NPSR1, TACR1, OPRL1 | HPGD 1802/4885KMT2A 2924/4885SMN1; SMN2 4092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.