Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | YWHAG | P61981 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622573 | 0.95 | HTR3A (0.42) | CHRNB2CHRNA4PIM1KDM4EMEN1 | |
| SCHEMBL5621961 | 0.87 | CHRNB2 (0.43) | CHRNB2CHRNA4PIM1GFERHTR3A | |
| SCHEMBL7705451 | 0.87 | CHRNB2 (0.48) | CHRNB2CHRNA4PIM1HTR3AHRH4 | |
| SCHEMBL5621943 | 0.85 | CHRNB2 (0.44) | CHRNB2CHRNA4PIM1HTR3AHRH4 | |
| SCHEMBL5620211 | 0.84 | CHRNB2 (0.41) | CHRNB2CHRNA4PIM1KDM4EMEN1 | |
| SCHEMBL5621910 | 0.82 | HTR3A (0.48) | CHRNB2CHRNA4PIM1HTR3APRKCA | |
| SCHEMBL5621369 | 0.82 | CHRM2 (0.41) | CHRNB2CHRNA4PIM1GFERHTR3A | |
| SCHEMBL5620167 | 0.81 | PARP1 (0.50) | CHRNB2CHRNA4PARP1 | |
| SCHEMBL5622576 | 0.79 | ITGB3 (0.42) | PIM1KDM4EMEN1KMT2AHTR3A | |
| SCHEMBL5621810 | 0.77 | HTR3A (0.52) | KDM4EMEN1KMT2AHTR3ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39608-E1 | Substituted benzimidazoles and their use as PARP inhibitors | ABBOTT GMBH & CO. KG (DE) | 2007-05-01 | — | — | US | disclosed |
| US-6448271-B1 | SUCH AS 2-(PIPERIDIN-4-YL)BENZIMIDAZOLE-4-CARBOXAMIDE; INHIBITORS OF ENZYME POLY(ADP-RIBOSE)POLYMERASE; IMPROVED WATER SOLUBILITY | BASF AKTIENGESELLSCHAFT (DE) | 2002-09-10 | — | — | US | disclosed |