Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063221 | 0.88 | NLRP3 (0.43) | CYP11B2CYP11B1RPS6KA5AGTR1AGTR2 | |
| SCHEMBL3059869 | 0.83 | CYP11B1 (0.41) | CYP11B2CYP11B1RPS6KA5AGTR1AGTR2 | |
| SCHEMBL3050438 | 0.83 | CYP11B1 (0.41) | CYP11B2CYP11B1RPS6KA5AGTR1AGTR2 | |
| SCHEMBL3070468 | 0.83 | MAPT (0.46) | CYP11B2CYP11B1RPS6KA5AGTR1AGTR2 | |
| SCHEMBL3065899 | 0.83 | CYP11B2 (0.39) | CYP11B2CYP11B1RPS6KA5MAP4K1ALDH1A1 | |
| SCHEMBL3061263 | 0.83 | CYP11B2 (0.42) | CYP11B2CYP11B1RPS6KA5AGTR1AGTR2 | |
| SCHEMBL3065922 | 0.83 | RPS6KA5 (0.42) | CYP11B2CYP11B1RPS6KA5AGTR1AGTR2 | |
| SCHEMBL3049258 | 0.82 | CYP11B1 (0.40) | CYP11B2CYP11B1RPS6KA5NLRP3ALDH1A1 | |
| SCHEMBL3065402 | 0.82 | TDP1 (0.42) | CYP11B2CYP11B1NLRP3GAAPKM | |
| SCHEMBL3064812 | 0.81 | CYP11B1 (0.39) | CYP11B2CYP11B1RPS6KA5AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300945-B2 | Benzimidazole and pyridylimidazole derivatives | NEUROGEN CORPORATION (US) | 2007-11-27 | — | — | US | disclosed |
| US-20060025425-A1 | Benzimidazole and pyridylimidazole derivatives | NEUROGEN CORPORATION | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025425-A1 | Benzimidazole and pyridylimidazole derivatives | GABBR1, GABBR2, GABRA2 | CYP11B2 47/4885CYP11B1 77/4885RPS6KA5 2860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.