Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PCK1 | P35558 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2524626 | 0.93 | ADORA2A (0.38) | ADORA2AADORA2BADORA1ALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL562271 | 0.92 | ADORA2A (0.36) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL562497 | 0.85 | ALDH1A1 (0.38) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL2530723 | 0.85 | ALDH1A1 (0.40) | ADORA2AADORA2BADORA1ALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL562306 | 0.81 | RXFP1 (0.37) | ADORA2AADORA2BADORA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL561757 | 0.81 | ADORA2A (0.42) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL562489 | 0.81 | ALDH1A1 (0.41) | ADORA2AADORA2BALDH1A1SMN1; SMN2 | |
| SCHEMBL562758 | 0.81 | ALDH1A1 (0.46) | ADORA2AADORA2BADORA1ALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL562294 | 0.81 | ADORA2A (0.41) | ADORA2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL561953 | 0.79 | ADORA2B (0.36) | ADORA2AADORA2BADORA1ADORA3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140371216-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2014-12-18 | — | — | US | disclosed |
| US-8703783-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120035172-A1 | Purinone Derivatives as HM74A Agonists | INCYTE CORPORATION (US) | 2012-02-09 | — | — | US | disclosed |
| US-8039478-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |
| US-20090286774-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
| US-7511050-B2 | hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors; avoiding adverse effects such as hepatotoxicity and cutaneous flushing; low dosage; 2-bromo-8-methyl-4-pentyl-1,4-dihydro-5H-[1,2,4]triazolo[5,1-i]purin-5-one; to treat cardiovascular disorders | INCYTE CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-20080045554-A1 | hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors; avoiding adverse effects such as hepatotoxicity and cutaneous flushing; low dosage; 2-bromo-8-methyl-4-pentyl-1,4-dihydro-5H-[1,2,4]triazolo[5,1-i]purin-5-one; to treat cardiovascular disorders | INCYTE CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371216-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2A 12/4885ADORA2B 68/4885ADORA1 39/4885 |
| US-20120035172-A1 | Purinone Derivatives as HM74A Agonists | GPR84, P2RY1, ADRA1A | ADORA2A 12/4885ADORA2B 68/4885ADORA1 39/4885 |
| US-20090286774-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2A 12/4885ADORA2B 68/4885ADORA1 39/4885 |
| US-20080045554-A1 | hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors; avoiding adverse effects such as hepatotoxicity and cutaneous flushing; low dosage; 2-bromo-8-methyl-4-pentyl-1,4-dihydro-5H-[1,2,4]triazolo[5,1-i]purin-5-one; to treat cardiovascular disorders | HMGCR, LDLR, GPBAR1 | ADORA2A 24/4885ADORA2B 177/4885ADORA1 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.