Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.62 |
| ▸ | GHSR | Q92847 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | LPL | P06858 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8528672 | 0.98 | SLC6A2 (0.61) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL228926 | 0.82 | SLC6A2 (0.67) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL18811661 | 0.81 | SLC6A2 (0.43) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL10891421 | 0.80 | SLC6A2 (0.64) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL5708352 | 0.80 | SLC6A2 (0.64) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| Hydrochloric Acid SCHEMBL5831539 | 0.80 | SLC6A2 (0.64) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL15706822 | 0.79 | ESR1 (0.61) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL25342534 | 0.78 | SLC6A2 (0.61) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL349725 | 0.78 | SLC6A2 (0.61) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| Hydrochloric Acid SCHEMBL3638960 | 0.78 | SLC6A2 (0.61) | SLC6A2HTR2ASLC6A4HRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102056897-B | Sulfonamide compound and application thereof | ASAHI KASEI PHARMA CORP | 2014-05-07 | — | — | CN | disclosed |
| EP-1562603-B3 | NOVEL MEDICAMENTS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES | BOEHRINGER INGELHEIM PHARMA (DE) | 2014-01-08 | — | — | EP | disclosed |
| EP-1765355-B1 | BENZOXAZINE FOR TREATING RESPIRATORY TRACT DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2292592-B1 | SULFONAMIDE COMPOUND AND APPLICATION THEREOF | ASAHI KASEI PHARMA CORP (JP) | 2012-09-05 | — | — | EP | disclosed |
| US-20120035169-A1 | AEROSOL FORMULATION FOR THE INHALATION OF BETA-AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-09 | — | — | US | disclosed |
| US-8044046-B2 | Medicaments for the treatment of chronic obstructive pulmonary disease | BOEHRINGER INGELHEIM PHARMA GMBH & CO KG (DE) | 2011-10-25 | — | — | US | disclosed |
| US-8039514-B2 | Sulfonamide compounds and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |
| US-8039514-B2 | Sulfonamide compounds and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |
| US-8039514-B2 | Sulfonamide compounds and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |
| CN-102056897-A | Sulfonamide compound and application thereof | ASAHI KASEI PHARMA CORP | 2011-05-11 | — | — | CN | disclosed |
| EP-1562603-A2 | NOVEL MEDICAMENTS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-08-17 | — | — | EP | disclosed |
| EP-0901459-B1 | CALCILYTIC COMPOUNDS | NPS PHARMA INC (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20050032850-A1 | Calcilytic compounds | NPS PHARMACEUTICALS, INC. | 2005-02-10 | — | — | US | disclosed |
| US-6818660-B2 | FOR INHIBITING CALCIUM RECEPTOR ACTIVIT; TO STIMULATE SECRETION OF PARATHYROID HORMONE (PTH); FOR BONE FORMATION | NPS PHARMACEUTICALS, INC. | 2004-11-16 | — | — | US | disclosed |
| US-20040147513-A1 | New medicaments for the treatment of chronic obstructive pulmonary disease | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-07-29 | — | — | US | disclosed |
| WO-2004045618-A2 | NOVEL MEDICAMENTS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-06-03 | — | — | WO | disclosed |
| US-6521667-B1 | Calcilytic compounds | NPS PHARMACEUTICALS, INC. | 2003-02-18 | — | — | US | disclosed |
| US-6432656-B1 | Calcilytic compounds | NPS PHARMACEUTICALS, INC. | 2002-08-13 | — | — | US | disclosed |
| US-20020099220-A1 | Calcilytic compounds | NPS PHARMACEUTICALS, INC. | 2002-07-25 | — | — | US | disclosed |
| US-6022894-A | Method of using calcilytic compounds | NPS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032850-A1 | Calcilytic compounds | CALCR, CASR, ORAI1 | SLC6A2 1690/4885HTR2A 2600/4885SLC6A4 2160/4885 |
| US-20040147513-A1 | New medicaments for the treatment of chronic obstructive pulmonary disease | CLIC1, OTC, SLC10A1 | SLC6A2 2004/4885HTR2A 3674/4885SLC6A4 2410/4885 |
| US-20120035169-A1 | AEROSOL FORMULATION FOR THE INHALATION OF BETA-AGONISTS | ADRB1, ADRB2, ADRB3 | SLC6A2 1271/4885HTR2A 1144/4885SLC6A4 2757/4885 |
| US-20020099220-A1 | Calcilytic compounds | CALCR, CASR, CALCRL | SLC6A2 1481/4885HTR2A 2663/4885SLC6A4 1864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.