Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13518610 | 0.98 | ABL1 (0.45) | ABL1KCNH3ALDH1A1MAPTNPC1 | |
| SCHEMBL6193428 | 0.86 | — | — | |
| SCHEMBL18906080 | 0.81 | ALDH1A1 (0.51) | KCNH3ALDH1A1MAPTTSHRGPR84 | |
| SCHEMBL9188922 | 0.81 | MARS1 (0.40) | ALDH1A1MAPTSIGMAR1 | |
| SCHEMBL9190311 | 0.81 | MARS1 (0.40) | ALDH1A1MAPTSIGMAR1 | |
| SCHEMBL9188361 | 0.81 | MARS1 (0.40) | ALDH1A1MAPTSIGMAR1 | |
| SCHEMBL18906062 | 0.79 | ALDH1A1 (0.50) | KCNH3ALDH1A1MAPTTSHRGPR84 | |
| SCHEMBL9190536 | 0.78 | MARS1 (0.38) | ALDH1A1MAPTNPC1SIGMAR1 | |
| SCHEMBL18906084 | 0.78 | TAAR1 (0.41) | ALDH1A1MAPTHRH3 | |
| SCHEMBL1492016 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023083330-A1 | DRAK2 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 百极优棠(广东)医药科技有限公司 | 2023-05-19 | — | — | WO | disclosed |
| US-20120035199-A9 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2012-02-09 | — | — | US | disclosed |
| EP-1888592-B1 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2011-04-06 | — | — | EP | disclosed |
| US-20110034500-A1 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2011-02-10 | — | — | US | disclosed |
| US-7799798-B2 | Spiroheterocyclic compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2010-09-21 | — | — | US | disclosed |
| US-20080103151-A9 | Heterocyclic compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2008-05-01 | — | — | US | disclosed |
| EP-1888592-A1 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-02-20 | — | — | EP | disclosed |
| EP-1879892-A2 | 2-PYRROLIDONE DERIVATIVES AND THEIR USES FOR THE TREATMENT OF INFLAMMATORY CONDITIONS AND PAIN | XENON PHARMACEUTICALS INC. (CA) | 2008-01-23 | — | — | EP | disclosed |
| US-20060258659-A1 | Heterocyclic compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2006-11-16 | — | — | US | disclosed |
| US-20060252758-A1 | Spiroheterocyclic compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2006-11-09 | — | — | US | disclosed |
| WO-2006113875-A2 | 2 - PYRROLIDONE DERIVATIVES AND THEIR USES FOR THE TREATMENT OF INFLAMMATORY CONDITIONS AND PAIN | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | disclosed |
| WO-2006110654-A1 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-19 | — | — | WO | disclosed |
| JP-2003306487-A | METHOD FOR PRODUCING 3-ACYLAMINO-THIOPHENE DERIVATIVE | MITSUI CHEMICALS INC | 2003-10-28 | — | — | JP | disclosed |
| EP-0737682-B1 | Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient | MITSUI CHEMICALS INC (JP) | 2002-01-09 | — | — | EP | disclosed |
| US-5747518-A | EFFECTIVE AGAINST CHEMICAL RESISTANT FUNGI; NONPHYTOTOXIC TO CROPS | MITSUI TOATSU CHEMICALS, INC. (JP) | 1998-05-05 | — | — | US | disclosed |
| EP-0737682-A1 | Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1996-10-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258659-A1 | Heterocyclic compounds and their uses as therapeutic agents | TRPV1, TRPV3, TRPV5 | ABL1 1656/4885KCNH3 57/4885ALDH1A1 807/4885 |
| US-20060252758-A1 | Spiroheterocyclic compounds and their uses as therapeutic agents | SCN3A, SCN1B, SCN2B | ABL1 3648/4885KCNH3 14/4885ALDH1A1 1435/4885 |
| US-20080103151-A9 | Heterocyclic compounds and their uses as therapeutic agents | TRPV1, TRPV3, TRPV5 | ABL1 1656/4885KCNH3 57/4885ALDH1A1 807/4885 |
| US-20110034500-A1 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | SCN3A, SCN1B, SCN2B | ABL1 3605/4885KCNH3 27/4885ALDH1A1 1200/4885 |
| US-20120035199-A9 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | SCN3A, SCN1B, SCN2B | ABL1 3605/4885KCNH3 27/4885ALDH1A1 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.