SCHEMBL5632397

SCHEMBL5632397

O=C(O)Nc1cccc(OC2CCN(c3ccncc3)CC2)c1

nearest known ligand 0.58

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
F10 P00742 18/20 0.58
F2 P00734 4/20 0.54
ELANE P08246 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5632393 0.86 NAMPT (0.56) F10
SCHEMBL7119023 0.85 F10 (0.51) F10F2ELANE
SCHEMBL5632535 0.78 F10 (0.49) F10F2ELANE
SCHEMBL18280011 0.77 ALDH1A1 (0.46) F10F2
SCHEMBL5632000 0.77 ALDH1A1 (0.49) F10F2ELANE
SCHEMBL5632002 0.77 ALDH1A1 (0.49) F10F2ELANE
SCHEMBL10260514 0.76 HTR1F (0.52) F2
SCHEMBL21391336 0.76 CSF1R (0.57) F2
Hydrochloric Acid SCHEMBL4504668 0.76 HTR1F (0.51) F2
SCHEMBL5632729 0.75 F2 (0.55) F10F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7173025-B1 Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents ZENECA LIMITED (GB) 2007-02-06 US disclosed
EP-0880502-B1 AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS ASTRAZENECA AB (SE) 2004-09-01 EP disclosed