Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2430216 | 0.77 | DRD1 (0.43) | ALDH1A1HPGDKDM4ECES1BCHE | |
| SCHEMBL29940483 | 0.77 | DRD1 (0.43) | ALDH1A1HPGDKDM4ECES1BCHE | |
| SCHEMBL7411028 | 0.74 | AHR (0.52) | KDM4ECES1DRD1DRD3HRH1 | |
| SCHEMBL1472457 | 0.73 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4ECES1BCHE | |
| SCHEMBL14441607 | 0.72 | CYP1A2 (0.67) | ALDH1A1HPGDKDM4ECES1BCHE | |
| SCHEMBL31392781 | 0.72 | CYP1A2 (0.67) | ALDH1A1HPGDKDM4ECES1BCHE | |
| SCHEMBL9409761 | 0.72 | HRH1 (0.47) | ALDH1A1HPGDKDM4ECES1BCHE | |
| SCHEMBL30310960 | 0.72 | HRH1 (0.47) | ALDH1A1HPGDKDM4ECES1BCHE | |
| SCHEMBL31392106 | 0.72 | CES1 (0.67) | ALDH1A1HPGDKDM4ECES1BCHE | |
| SCHEMBL3638469 | 0.72 | CES1 (0.67) | ALDH1A1HPGDKDM4ECES1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404729-B2 | Heterocyclic tetracyclic tetrahydrofuran derivatives | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-26 | — | — | US | disclosed |
| US-20120238563-A1 | NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | CID-NUNEZ JOSE MARIA (ES) | 2012-09-20 | — | — | US | disclosed |
| US-20120035170-A1 | NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | NUNEZ JOSE MARIA (ES) | 2012-02-09 | — | — | US | disclosed |
| US-8022102-B2 | Unsaturated tetracyclic tetrahydrofuran derivatives | JANSSEN PHARMACEUTICA, NV (BE) | 2011-09-20 | — | — | US | disclosed |
| US-20110144094-A1 | HETEROCYCLIC TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | CID-NUNEZ JOSE MARIA | 2011-06-16 | — | — | US | disclosed |
| US-20110144094-A1 | HETEROCYCLIC TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | CID-NUNEZ JOSE MARIA | 2011-06-16 | — | — | US | disclosed |
| US-7915249-B2 | serotonin 5-HT2A, 5-HT2C and dopamin D2 receptors antagonist, and norepinephrine reuptake inhibitor; antidepressant, anxiolytic agent; psychosis, schizophrenia, bipolar and sexual disorders, obesity | JANSSEN PHARMACEUTICAL NV (BE) | 2011-03-29 | — | — | US | disclosed |
| US-20080108599-A1 | Heterocyclic Tetracyclic Tetrahydrofuran Derivatives As 5Ht2 Inhibitors In The Treatment Of Cns Disorders | JANSSEN-CILAG S.A. (ES) | 2008-05-08 | — | — | US | disclosed |
| US-20070191469-A1 | Novel tetracyclic tetrahydrofuran derivatives | JANSSEN-CILAG S.A. (ES) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035170-A1 | NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | HTR2C, HTR2A, HTR1A | ALDH1A1 287/4885HPGD 399/4885KDM4E 4791/4885 |
| US-20080108599-A1 | Heterocyclic Tetracyclic Tetrahydrofuran Derivatives As 5Ht2 Inhibitors In The Treatment Of Cns Disorders | HTR2C, HTR2A, TPH2 | ALDH1A1 580/4885HPGD 620/4885KDM4E 4647/4885 |
| US-20070191469-A1 | Novel tetracyclic tetrahydrofuran derivatives | HTR2C, HTR2A, HTR1A | ALDH1A1 349/4885HPGD 620/4885KDM4E 4793/4885 |
| US-20110144094-A1 | HETEROCYCLIC TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | HTR2C, HTR2A, HTR5A | ALDH1A1 346/4885HPGD 444/4885KDM4E 4710/4885 |
| US-20120238563-A1 | NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | HTR2C, HTR2A, HTR1A | ALDH1A1 287/4885HPGD 399/4885KDM4E 4791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.