Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5633809 | 0.99 | TDP1 (0.56) | TDP1L3MBTL1MAPTMEN1USP2 | |
| SCHEMBL5633422 | 0.83 | MAPT (0.43) | TDP1L3MBTL1MAPTMEN1USP2 | |
| SCHEMBL5442584 | 0.78 | MAPT (0.67) | TDP1L3MBTL1MAPTMEN1USP2 | |
| SCHEMBL5633577 | 0.77 | HTT (0.49) | L3MBTL1MAPTKMT2AFAAHSMN1; SMN2 | |
| SCHEMBL5632662 | 0.74 | L3MBTL1 (0.48) | TDP1L3MBTL1MAPTMEN1USP2 | |
| SCHEMBL14560433 | 0.74 | ELANE (0.58) | TDP1L3MBTL1MAPTMEN1USP2 | |
| SCHEMBL5633513 | 0.73 | ALDH1A1 (0.46) | MAPTMGLLALDH1A1ALDH2PKM | |
| SCHEMBL5440814 | 0.73 | MAPT (0.69) | TDP1L3MBTL1MAPTMEN1USP2 | |
| SCHEMBL8143587 | 0.73 | TDP1 (0.60) | TDP1L3MBTL1MAPTKMT2AFAAH | |
| SCHEMBL5634864 | 0.73 | TDP1 (0.50) | TDP1L3MBTL1MAPTMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123548-A1 | Pth agonists | COWAN DAVID J | 2007-05-31 | — | — | US | claimed |
| EP-1713782-A1 | PTH AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-25 | — | — | EP | claimed |
| WO-2005077918-A1 | PTH AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | claimed |
| US-20070123548-A1 | Pth agonists | COWAN DAVID J | 2007-05-31 | — | — | US | disclosed |
| EP-1713782-A1 | PTH AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005077918-A1 | PTH AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123548-A1 | Pth agonists | PTH1R, SSTR3, CALCR | TDP1 4833/4885L3MBTL1 4667/4885MAPT 4835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.