Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 0.92 |
| ▸ | HTR2B | P41595 | 7/20 | 0.57 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5394177 | 1.00 | HTR2C (0.92) | HTR2CHTR2BHTR2A | |
| SCHEMBL20698202 | 0.99 | HTR2C (0.94) | HTR2CHTR2BHTR2A | |
| SCHEMBL7229772 | 0.99 | HTR2C (0.94) | HTR2CHTR2BHTR2A | |
| SCHEMBL4344616 | 0.96 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL16168362 | 0.96 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL4352287 | 0.96 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL29434863 | 0.96 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL4354419 | 0.96 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL5739640 | 0.86 | HTR2C (0.73) | HTR2CHTR2BHTR2A | |
| SCHEMBL5739869 | 0.86 | HTR2C (0.73) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271164-B2 | Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives | WYETH (US) | 2007-09-18 | — | — | US | claimed |
| US-20050054635-A1 | Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives | WYETH (US) | 2005-03-10 | — | — | US | claimed |
| US-6858604-B2 | Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | WYETH (US) | 2005-02-22 | — | — | US | claimed |
| US-20020128261-A1 | Cyclohepta [b] [1,4] diazepino [6,7, 1-hi] indoles and derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-09-12 | — | — | US | claimed |
| WO-2002036596-A2 | CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES | WYETH (US) | 2002-05-10 | — | — | WO | claimed |
| US-7271164-B2 | Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives | WYETH (US) | 2007-09-18 | — | — | US | disclosed |
| US-20050054635-A1 | Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives | WYETH (US) | 2005-03-10 | — | — | US | disclosed |
| US-6858604-B2 | Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | WYETH (US) | 2005-02-22 | — | — | US | disclosed |
| US-20020128261-A1 | Cyclohepta [b] [1,4] diazepino [6,7, 1-hi] indoles and derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-09-12 | — | — | US | disclosed |
| WO-2002036596-A2 | CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES | WYETH (US) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128261-A1 | Cyclohepta [b] [1,4] diazepino [6,7, 1-hi] indoles and derivatives | TPH1, HTR1A, FAAH | HTR2C 14/4885HTR2B 5/4885HTR2A 23/4885 |
| US-20050054635-A1 | Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives | TPH1, HTR1A, GRIN2B | HTR2C 25/4885HTR2B 5/4885HTR2A 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.