Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 1.00 |
| ▸ | HTR2B | P41595 | 7/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29434863 | 1.00 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL4352287 | 1.00 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL4344616 | 1.00 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL16168362 | 1.00 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL7229772 | 0.97 | HTR2C (0.94) | HTR2CHTR2BHTR2A | |
| SCHEMBL20698202 | 0.97 | HTR2C (0.94) | HTR2CHTR2BHTR2A | |
| SCHEMBL5633946 | 0.96 | HTR2C (0.92) | HTR2CHTR2BHTR2A | |
| SCHEMBL5394177 | 0.96 | HTR2C (0.92) | HTR2CHTR2BHTR2A | |
| SCHEMBL5739227 | 0.87 | HTR2C (0.78) | HTR2CHTR2BHTR2A | |
| SCHEMBL5739232 | 0.87 | HTR2C (0.78) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281091-A1 | METHODS FOR MODULATING BLADDER FUNCTION | WYETH (US) | 2009-11-12 | — | — | US | claimed |
| EP-1998773-A2 | NEW THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF DEPRESSION | Wyeth a Corporation of the State of Delaware (US) | 2008-12-10 | — | — | EP | claimed |
| US-20080009480-A1 | CYCLOPENTA[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES | WYETH (US) | 2008-01-10 | — | — | US | claimed |
| US-20070238725-A1 | Therapeutic combinations for the treatment or prevention of psychotic disorders | WYETH (US) | 2007-10-11 | — | — | US | claimed |
| WO-2007112014-A2 | NEW THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2007-10-04 | — | — | WO | claimed |
| US-20070225279-A1 | Therapeutic combinations for the treatment of depression | WYETH (US) | 2007-09-27 | — | — | US | claimed |
| US-20070225277-A1 | Treatment of pain | WYETH (US) | 2007-09-27 | — | — | US | claimed |
| US-20070225278-A1 | Methods for treating cognitive and other disorders | WYETH (US) | 2007-09-27 | — | — | US | claimed |
| US-20070225274-A1 | Methods for modulating bladder function | WYETH (US) | 2007-09-27 | — | — | US | claimed |
| US-7271163-B2 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | WYETH (US) | 2007-09-18 | — | — | US | claimed |
| US-20050004101-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | WYETH (US) | 2005-01-06 | — | — | US | claimed |
| EP-1330457-B1 | CYCLOPENTA[B][1,4] DIAZEPINO[6,7,1-HI]INDOLES AS 5HT2C ANTAGONISTS | WYETH CORP (US) | 2004-10-20 | — | — | EP | claimed |
| US-6777407-B2 | 7BH-CYCLOPENTA(B)(1,4)DIAZEPINO(6, 7, 1-HI)INDOLE OR A SALT, USEFUL FOR TREATMENT OF SCHIZOPHRENIA, OBSESSIVE COMPULSIVE DISORDER, DEPRESSION, ANXIETY, PANIC DISORDER, OBESITY OR EPILEPSY | WYETH | 2004-08-17 | — | — | US | claimed |
| US-20020107242-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-08-08 | — | — | US | claimed |
| US-20150238506-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-08-27 | — | — | US | disclosed |
| US-9079907-B2 | Fused heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-07-14 | — | — | US | disclosed |
| EP-2789338-A2 | Condensed pyridine derivate and use thereof | Takeda Pharmaceutical Company Limited (JP) | 2014-10-15 | — | — | EP | disclosed |
| US-20020055630-A1 | Such as (2S)-(rel-7bR,10aR)-2-Methyl-1,2,3,4,8,9,10,10a-octahydro-7bH -Cyclopenta(b)(1,4)Diazepino(6,7,1-hi)indole; for treatment of obesity | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-09 | — | — | US | disclosed |
| US-20020055630-A1 | Such as (2S)-(rel-7bR,10aR)-2-Methyl-1,2,3,4,8,9,10,10a-octahydro-7bH -Cyclopenta(b)(1,4)Diazepino(6,7,1-hi)indole; for treatment of obesity | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-09 | — | — | US | disclosed |
| US-20020055504-A1 | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [b] [1,4] diazepino- [6,7,1-hi] indole derivatives | WYETH | 2002-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107242-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | CNR1, HCRTR1, HTR3C | HTR2C 14/4885HTR2B 17/4885HTR2A 32/4885 |
| US-20070238725-A1 | Therapeutic combinations for the treatment or prevention of psychotic disorders | SLC6A3, GRIN2A, GRIN2C | HTR2C 700/4885HTR2B 933/4885HTR2A 847/4885 |
| US-20090281091-A1 | METHODS FOR MODULATING BLADDER FUNCTION | PDE3A, PDE3B, PDE2A | HTR2C 1494/4885HTR2B 1580/4885HTR2A 1749/4885 |
| US-20070225279-A1 | Therapeutic combinations for the treatment of depression | BDNF, GRIN2A, GRIN3A | HTR2C 172/4885HTR2B 252/4885HTR2A 157/4885 |
| US-20020055504-A1 | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [b] [1,4] diazepino- [6,7,1-hi] indole derivatives | CYP8B1, HTR2B, HTR1A | HTR2C 35/4885HTR2B 2/4885HTR2A 22/4885 |
| US-20050004101-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | CNR1, HCRTR1, HTR3C | HTR2C 21/4885HTR2B 16/4885HTR2A 34/4885 |
| US-20070225277-A1 | Treatment of pain | OPRL1, OPRK1, OPRM1 | HTR2C 894/4885HTR2B 973/4885HTR2A 868/4885 |
| US-20070225274-A1 | Methods for modulating bladder function | PDE3A, PDE3B, PDE2A | HTR2C 1494/4885HTR2B 1580/4885HTR2A 1749/4885 |
| US-20070225278-A1 | Methods for treating cognitive and other disorders | CHAT, COMT, ACHE | HTR2C 25/4885HTR2B 69/4885HTR2A 31/4885 |
| US-20020055630-A1 | Such as (2S)-(rel-7bR,10aR)-2-Methyl-1,2,3,4,8,9,10,10a-octahydro-7bH -Cyclopenta(b)(1,4)Diazepino(6,7,1-hi)indole; for treatment of obesity | REL, HTR3B, HTR1B | HTR2C 15/4885HTR2B 4/4885HTR2A 18/4885 |
| US-20150238506-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | HTR2C, HTR3C, HTR3B | HTR2C 1/4885HTR2B 5/4885HTR2A 4/4885 |
| US-20080009480-A1 | CYCLOPENTA[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES | CNR1, HCRTR1, HTR3C | HTR2C 21/4885HTR2B 16/4885HTR2A 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.