Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 12/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634175 | 0.81 | MAPK14 (0.60) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL5634588 | 0.80 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5633790 | 0.80 | MAPK13 (0.62) | MAPK13MAPK12MAPK11MAPK14RAB9A | |
| SCHEMBL5635009 | 0.80 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6469458 | 0.78 | SMN1; SMN2 (0.46) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL5555188 | 0.76 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14GAA | |
| Aniline SCHEMBL27477022 | 0.74 | MAPK14 (0.48) | MAPK13MAPK12MAPK11MAPK14CCNK | |
| SCHEMBL2470790 | 0.73 | MAPK13 (0.47) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL5634021 | 0.72 | MAPK13 (0.65) | MAPK13MAPK12MAPK11MAPK14NCOA1 | |
| SCHEMBL5634446 | 0.72 | RAB9A (0.54) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100381429-C | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2008-04-16 | — | — | CN | disclosed |
| US-7253197-B2 | Aminothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| CN-1675188-A | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | CN | disclosed |
| US-20040038990-A1 | Aminothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038990-A1 | Aminothiazole derivatives | FABP4, GPR119, ABAT | MAPK13 3018/4885MAPK12 2608/4885MAPK11 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.