Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634010 | 0.78 | MAPK13 (0.57) | SMN1; SMN2GAAHTTNCOA1NCOA3 | |
| SCHEMBL2470790 | 0.74 | MAPK13 (0.47) | GAAMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6644387 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2GAAHTTNCOA1NCOA3 | |
| SCHEMBL14517067 | 0.71 | ALDH1A1 (0.47) | SMN1; SMN2GAAHTTNCOA1NCOA3 | |
| SCHEMBL975117 | 0.68 | ALDH1A1 (0.68) | SMN1; SMN2GAAHTTNCOA1NCOA3 | |
| SCHEMBL11903255 | 0.68 | ALDH1A1 (0.54) | SMN1; SMN2GAAHTTNCOA1NCOA3 | |
| Pyridine SCHEMBL27540706 | 0.67 | ALDH1A1 (0.56) | SMN1; SMN2GAAHTTNCOA1NCOA3 | |
| SCHEMBL6942456 | 0.66 | HTT (0.63) | SMN1; SMN2GAAHTTNCOA1NCOA3 | |
| SCHEMBL7112516 | 0.66 | NPC1 (0.61) | SMN1; SMN2GAAHTTNCOA1NCOA3 | |
| SCHEMBL1207703 | 0.65 | ALDH1A1 (0.48) | SMN1; SMN2GAAHTTNCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539722-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004014884-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-02-19 | — | — | WO | disclosed |