Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PCK1 | P35558 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522523 | 0.92 | ADORA2A (0.46) | ADORA2AALDH1A1SMN1; SMN2HTTKDM4E | |
| Trifluoroacetic Acid SCHEMBL562501 | 0.89 | ADORA2A (0.44) | ADORA2AALDH1A1SMN1; SMN2NPSR1PCK1 | |
| Trifluoroacetic Acid SCHEMBL562117 | 0.87 | ADORA2A (0.41) | ADORA2AALDH1A1SMN1; SMN2NPSR1PCK1 | |
| Trifluoroacetic Acid SCHEMBL563148 | 0.86 | ADORA2A (0.40) | ADORA2AALDH1A1SMN1; SMN2PCK1HTT | |
| Trifluoroacetic Acid SCHEMBL561998 | 0.85 | ADORA2A (0.38) | ADORA2AALDH1A1NPSR1PCK1KDM4E | |
| Trifluoroacetic Acid SCHEMBL562294 | 0.85 | ADORA2A (0.41) | ADORA2AALDH1A1HTTTDP1POLB | |
| Trifluoroacetic Acid SCHEMBL562778 | 0.83 | APLNR (0.38) | ADORA2AALDH1A1SMN1; SMN2NPSR1HTT | |
| Trifluoroacetic Acid SCHEMBL563370 | 0.83 | ALDH1A1 (0.35) | ADORA2AALDH1A1SMN1; SMN2PCK1ADORA1 | |
| SCHEMBL562116 | 0.83 | ADORA2A (0.52) | ADORA2AALDH1A1SMN1; SMN2CYP1A2CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL563539 | 0.83 | ADORA2A (0.38) | ADORA2AALDH1A1SMN1; SMN2PCK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140371216-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2014-12-18 | — | — | US | disclosed |
| US-8703783-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120035172-A1 | Purinone Derivatives as HM74A Agonists | INCYTE CORPORATION (US) | 2012-02-09 | — | — | US | disclosed |
| US-8039478-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |
| US-20090286774-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
| EP-2044074-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | Incyte Corporation (US) | 2009-04-08 | — | — | EP | disclosed |
| US-7511050-B2 | hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors; avoiding adverse effects such as hepatotoxicity and cutaneous flushing; low dosage; 2-bromo-8-methyl-4-pentyl-1,4-dihydro-5H-[1,2,4]triazolo[5,1-i]purin-5-one; to treat cardiovascular disorders | INCYTE CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-20080045554-A1 | hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors; avoiding adverse effects such as hepatotoxicity and cutaneous flushing; low dosage; 2-bromo-8-methyl-4-pentyl-1,4-dihydro-5H-[1,2,4]triazolo[5,1-i]purin-5-one; to treat cardiovascular disorders | INCYTE CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
| WO-2007150025-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371216-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2A 12/4885ALDH1A1 641/4885SMN1; SMN2 1165/4885 |
| US-20120035172-A1 | Purinone Derivatives as HM74A Agonists | GPR84, P2RY1, ADRA1A | ADORA2A 12/4885ALDH1A1 641/4885SMN1; SMN2 1165/4885 |
| US-20090286774-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2A 12/4885ALDH1A1 641/4885SMN1; SMN2 1165/4885 |
| US-20080045554-A1 | hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors; avoiding adverse effects such as hepatotoxicity and cutaneous flushing; low dosage; 2-bromo-8-methyl-4-pentyl-1,4-dihydro-5H-[1,2,4]triazolo[5,1-i]purin-5-one; to treat cardiovascular disorders | HMGCR, LDLR, GPBAR1 | ADORA2A 24/4885ALDH1A1 181/4885SMN1; SMN2 4478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.