Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 1/20 | 0.80 |
| ▸ | ATP4B | P51164 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9165498 | 0.99 | ATP4A (0.79) | ATP4AATP4B | |
| SCHEMBL9165510 | 0.99 | ATP4A (0.79) | ATP4AATP4B | |
| Hydrochloric Acid SCHEMBL9264291 | 0.99 | ATP4A (0.79) | ATP4AATP4B | |
| SCHEMBL9267721 | 0.96 | ATP4A (0.75) | ATP4AATP4B | |
| SCHEMBL10535714 | 0.95 | ATP4A (0.73) | ATP4AATP4B | |
| SCHEMBL9269697 | 0.94 | ATP4A (0.75) | ATP4AATP4B | |
| SCHEMBL9269453 | 0.94 | ATP4A (0.75) | ATP4AATP4B | |
| SCHEMBL9157247 | 0.93 | ATP4A (0.69) | ATP4AATP4B | |
| SCHEMBL9269573 | 0.91 | ATP4A (0.82) | ATP4AATP4B | |
| SCHEMBL9157119 | 0.90 | ATP4A (0.76) | ATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179150-A1 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2007-08-02 | — | — | US | claimed |
| EP-1534278-A4 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2006-09-06 | — | — | EP | claimed |
| JP-2005539013-A | — | — | 2005-12-22 | — | — | JP | claimed |
| EP-1534278-A2 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| EP-1154771-A4 | NITROSATED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2005-04-20 | — | — | EP | claimed |
| US-6852739-B1 | Methods using proton pump inhibitors and nitric oxide donors | NITROMED INC. (US) | 2005-02-08 | — | — | US | claimed |
| US-20040266828-A1 | Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use | NITROMED, INC. (US) | 2004-12-30 | — | — | US | claimed |
| WO-2004012659-A2 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2004-02-12 | — | — | WO | claimed |
| US-20040024014-A1 | Nitrosated proton pump inhibitors, compositions and methods of use | NITROMED, INC. (US) | 2004-02-05 | — | — | US | claimed |
| EP-0841904-B1 | ORAL PHARMACEUTICAL COMPOSITIONS WITH DELAYED RELEASE OF REVERSIBLE PROTON PUMP INHIBITORS | ALTANA PHARMA AG (DE) | 2003-02-05 | — | — | EP | claimed |
| JP-2002537336-A | — | — | 2002-11-05 | — | — | JP | claimed |
| EP-1154771-A1 | NITROSATED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2001-11-21 | — | — | EP | claimed |
| US-6132768-A | FOR TREATING DISORDERS CAUSED BY HELICOBACTER | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-10-17 | — | — | US | claimed |
| WO-2000050037-A1 | NITROSATED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2000-08-31 | — | — | WO | claimed |
| EP-0841904-A1 | ORAL PHARMACEUTICAL COMPOSITIONS WITH DELAYED RELEASE OF REVERSIBLE PROTON PUMP INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1998-05-20 | — | — | EP | claimed |
| WO-1997002021-A1 | ORAL PHARMACEUTICAL COMPOSITIONS WITH DELAYED RELEASE OF REVERSIBLE PROTON PUMP INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1997-01-23 | — | — | WO | claimed |
| EP-0330485-B1 | 4-AMINO-3-ACYL QUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF GASTRIC ACID SECRETION | SmithKline Beecham Intercredit B.V. (NL) | 1993-05-26 | — | — | EP | claimed |
| US-5089504-A | SUBSTITUTED 4-AMINOQUINOLINE DERIVATIVES AS GASTRIC ACID SECRETION INHIBITORS | SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) | 1992-02-18 | — | — | US | claimed |
| US-9085508-B2 | Nitric oxide releasing amino acid ester compound, composition and method of use | ORAL DELIVERY TECHNOLOGY LTD. (US) | 2015-07-21 | — | — | US | disclosed |
| EP-0330485-A1 | 4-Amino-3-acyl quinoline derivatives and their use as inhibitors of gastric acid secretion | SmithKline Beecham Intercredit B.V. (NL) | 1989-08-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179150-A1 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NOS1, PTGS1, NOS2 | ATP4A 223/4885ATP4B 220/4885 |
| US-20040024014-A1 | Nitrosated proton pump inhibitors, compositions and methods of use | NOS1, PTGS1, NOS2 | ATP4A 223/4885ATP4B 220/4885 |
| US-20040266828-A1 | Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use | NOS2, NOS1, PTGS2 | ATP4A 242/4885ATP4B 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.