Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1642902 | 0.80 | CHRM2 (0.77) | CHRM2CA12CA1CA2CA4 | |
| SCHEMBL354774 | 0.78 | CHRM2 (0.68) | CHRM2CA12CA1CA2CA4 | |
| SCHEMBL7468419 | 0.77 | CHRM2 (0.67) | CHRM2CA12CA1CA2CA4 | |
| SCHEMBL13278276 | 0.76 | CHRM2 (0.85) | CHRM2CA12CA1CA2CA4 | |
| SCHEMBL30141723 | 0.76 | CHRM2 (0.92) | CHRM2CA12CA1CA2CA4 | |
| SCHEMBL843371 | 0.75 | CHRM2 (0.69) | CHRM2CA12CA1CA2CA4 | |
| Hydrochloric Acid SCHEMBL31169750 | 0.75 | CHRM2 (0.65) | CHRM2CA12CA1CA2CA4 | |
| SCHEMBL15379600 | 0.75 | ALDH1A1 (0.59) | TSHRALDH1A1POLBMAPTTDP1 | |
| SCHEMBL11069595 | 0.74 | CHRM2 (0.96) | CHRM2CA12CA1CA2CA4 | |
| SCHEMBL11073153 | 0.74 | CHRM2 (0.96) | CHRM2CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102918044-A | Fused quinazoline derivatives and uses thereof | SHENZHEN SALUBRIS PHARM CO LTD | 2013-02-06 | — | — | CN | claimed |
| US-20070099917-A1 | Novel inhibitors and methods for their preparation | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-05-03 | — | — | US | claimed |
| CN-105017162-B | 4 pairs of propenylbenzene amido quinazoline derivatives and its application in antineoplastic is prepared | 陕西师范大学 | 2017-10-27 | — | — | CN | disclosed |
| CN-105017162-B | 4 pairs of propenylbenzene amido quinazoline derivatives and its application in antineoplastic is prepared | 陕西师范大学 | 2017-10-27 | — | — | CN | disclosed |
| CN-102918044-A | Fused quinazoline derivatives and uses thereof | SHENZHEN SALUBRIS PHARM CO LTD | 2013-02-06 | — | — | CN | disclosed |
| CN-102532109-A | Synthetic method of lapatinib and salt of lapatinib | ZHEJIANG HISUN PHARM CO LTD | 2012-07-04 | — | — | CN | disclosed |
| US-20070099917-A1 | Novel inhibitors and methods for their preparation | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099917-A1 | Novel inhibitors and methods for their preparation | TK1, ABL1, FLT3 | CHRM2 4840/4885CA12 2843/4885CA1 2277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.