Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5635880 | 0.81 | GRIN2B (0.44) | OPRM1 | |
| SCHEMBL5780939 | 0.79 | OPRD1 (0.45) | OPRM1 | |
| SCHEMBL5785483 | 0.69 | SLC6A2 (0.33) | SLC6A2SLC6A4OPRM1CYP3A4LPAR1 | |
| SCHEMBL5578454 | 0.68 | HDAC1 (0.44) | — | |
| SCHEMBL5578642 | 0.67 | GRIN2B (0.45) | — | |
| SCHEMBL5599822 | 0.66 | NOTUM (0.52) | HSD11B1 | |
| SCHEMBL5599270 | 0.66 | NOTUM (0.33) | OPRM1 | |
| SCHEMBL5599280 | 0.64 | KCNA3 (0.34) | HSD11B1CYP3A4 | |
| SCHEMBL5635671 | 0.63 | EED (0.37) | OPRM1 | |
| SCHEMBL4116754 | 0.63 | ACE (0.35) | HSD11B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |