Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 2/20 | 0.37 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | NR1D1 | P20393 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5635880 | 0.81 | GRIN2B (0.44) | AVPR1AMEN1KMT2ANR1D1CBX7 | |
| SCHEMBL5599820 | 0.72 | SCN9A (0.37) | EEDMT-CO2GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL5578601 | 0.69 | AVPR1A (0.43) | ALDH1A1AVPR1AMEN1KMT2ASCN9A | |
| SCHEMBL5582419 | 0.68 | MEN1 (0.46) | SMN1; SMN2ALDH1A1AVPR1AMEN1KMT2A | |
| SCHEMBL5599341 | 0.66 | TSHR (0.33) | GAAALDH1A1MEN1KMT2AOPRM1 | |
| SCHEMBL5580211 | 0.66 | AVPR1A (0.43) | ALDH1A1AVPR1AMEN1KMT2A | |
| SCHEMBL5599778 | 0.63 | KMT2A (0.39) | ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL5599702 | 0.63 | HSD11B1 (0.35) | OPRM1 | |
| SCHEMBL5599270 | 0.63 | NOTUM (0.33) | OPRM1 | |
| SCHEMBL5599671 | 0.63 | KMT2A (0.33) | GAAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |