Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17602203 | 0.73 | SIGMAR1 (0.41) | DRD2DRD3ESR2DRD4 | |
| SCHEMBL23357194 | 0.59 | ESR2 (0.45) | DRD2DRD3HTR2AESR2DRD4 | |
| SCHEMBL30980858 | 0.59 | ESR2 (0.45) | DRD2DRD3HTR2AESR2DRD4 | |
| SCHEMBL23357190 | 0.59 | ESR2 (0.45) | DRD2DRD3HTR2AESR2DRD4 | |
| SCHEMBL4818995 | 0.56 | ESR2 (0.45) | DRD2DRD1DRD5DRD3ESR2 | |
| SCHEMBL8485819 | 0.56 | DRD1 (0.57) | DRD2DRD1DRD5DRD3ESR2 | |
| SCHEMBL10157726 | 0.56 | PDK2 (0.47) | DRD2DRD1DRD5DRD3ESR2 | |
| SCHEMBL14207342 | 0.55 | — | — | |
| SCHEMBL19088009 | 0.55 | ESR2 (0.47) | DRD2DRD3ESR2DRD4 | |
| SCHEMBL33917 | 0.54 | DRD2 (0.70) | DRD2DRD1DRD5DRD3ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268131-B2 | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma | ALCON, INC. (CH) | 2007-09-11 | — | — | US | disclosed |
| US-6989445-B2 | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma | ALCON, INC. (CH) | 2006-01-24 | — | — | US | disclosed |
| US-20050277636-A1 | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma | DANTANARAYANA ANURA P | 2005-12-15 | — | — | US | disclosed |
| WO-2005058911-A2 | SUBSTITUTED [1,4]OXAZINO[2,3-G]INDAZOLES FOR THE TREATMENT OF GLAUCOMA | ALCON, INC. (CH) | 2005-06-30 | — | — | WO | disclosed |
| US-20050130960-A1 | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma | ALCON, INC. | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277636-A1 | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma | PTGIS, PTGS1, PTGIR | DRD2 3172/4885DRD1 3412/4885DRD5 2588/4885 |
| US-20050130960-A1 | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma | PTGIS, PTGS1, PTGIR | DRD2 3172/4885DRD1 3412/4885DRD5 2588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.