Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426860 | 0.88 | ALDH1A1 (0.59) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL22579700 | 0.86 | ALDH1A1 (0.57) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL29749978 | 0.83 | ALDH1A1 (0.52) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL10714683 | 0.83 | ALDH1A1 (0.52) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL28338065 | 0.82 | CYP3A4 (0.40) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL6445803 | 0.82 | L3MBTL1 (0.49) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL5644726 | 0.82 | ALDH1A1 (0.50) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL17248024 | 0.81 | CYP1A2 (0.43) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL2611830 | 0.81 | ALDH1A1 (0.61) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL3065551 | 0.81 | ALDH1A1 (0.52) | CYP1A2CYP2D6CYP3A4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108586-B | Polycyclic anaplastic lymphoma kinase inhibitors | 山东轩竹医药科技有限公司 | 2020-07-10 | — | — | CN | disclosed |
| EP-3202765-B1 | POLYCYCLIC ANAPLASTIC LYMPHOMA KINASE INHIBITOR | HAINAN XUANZHU PHARMA CO LTD (CN) | 2020-03-25 | — | — | EP | disclosed |
| US-10011592-B2 | Polycyclic inhibitor of anaplastic lymphoma kinase | Xuanzhu Pharma Co., Ltd. (CN) | 2018-07-03 | — | — | US | disclosed |
| US-10011592-B2 | Polycyclic inhibitor of anaplastic lymphoma kinase | Xuanzhu Pharma Co., Ltd. (CN) | 2018-07-03 | — | — | US | disclosed |
| US-10011592-B2 | Polycyclic inhibitor of anaplastic lymphoma kinase | Xuanzhu Pharma Co., Ltd. (CN) | 2018-07-03 | — | — | US | disclosed |
| CN-104854101-B | Alk kinase inhibitors | 上海复尚慧创医药研究有限公司 | 2018-05-01 | — | — | CN | disclosed |
| US-20180086745-A9 | POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2018-03-29 | — | — | US | disclosed |
| US-20180086745-A9 | POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2018-03-29 | — | — | US | disclosed |
| US-20180086745-A9 | POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2018-03-29 | — | — | US | disclosed |
| CN-107108586-A | Polycyclic Anaplastic Lymphoma Kinase Inhibitors | 山东轩竹医药科技有限公司 | 2017-08-29 | — | — | CN | disclosed |
| EP-2917210-A1 | ALK KINASE INHIBITORS | Shanghai Fochon Pharmaceutical Co. Ltd (CN) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014071832-A1 | ALK KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN) | 2014-05-15 | — | — | WO | disclosed |
| WO-2014071832-A1 | ALK KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN) | 2014-05-15 | — | — | WO | disclosed |
| US-20140128387-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI iNSTITUTE OF MATERIA MEDICA ACADEMY OF SCIENCES (CN) | 2014-05-08 | — | — | US | disclosed |
| US-20140128387-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI iNSTITUTE OF MATERIA MEDICA ACADEMY OF SCIENCES (CN) | 2014-05-08 | — | — | US | disclosed |
| US-20140128387-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI iNSTITUTE OF MATERIA MEDICA ACADEMY OF SCIENCES (CN) | 2014-05-08 | — | — | US | disclosed |
| US-7163939-B2 | Macrocyclic kinase inhibitors | ABBOTT LABORATORIES (US) | 2007-01-16 | — | — | US | disclosed |
| EP-1682555-A1 | MACROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050215556-A1 | Macrocyclic kinase inhibitors | ABBVIE INC. | 2005-09-29 | — | — | US | disclosed |
| WO-2005047294-A1 | MACROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086745-A9 | POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE | IKBKE, DCK, CHUK | CYP1A2 2668/4885CYP2D6 3078/4885CYP3A4 2241/4885 |
| US-10011592-B2 | Polycyclic inhibitor of anaplastic lymphoma kinase | IKBKE, DCK, CHUK | CYP1A2 2668/4885CYP2D6 3078/4885CYP3A4 2241/4885 |
| US-20140128387-A1 | CERTAIN PROTEIN KINASE INHIBITORS | PRKACA, PRKDC, PRKACB | CYP1A2 4548/4885CYP2D6 4434/4885CYP3A4 4452/4885 |
| US-20050215556-A1 | Macrocyclic kinase inhibitors | MAP3K20, MAP3K19, MAP3K7 | CYP1A2 4327/4885CYP2D6 4079/4885CYP3A4 4166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.