Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15688613 | 1.00 | ADORA2A (0.37) | ADORA2AADORA2BADORA1POLBCYP2C9 | |
| SCHEMBL31126660 | 0.82 | ALDH1A1 (0.46) | POLBCYP2C9KDM4EALDH1A1MAPT | |
| SCHEMBL1419495 | 0.82 | CYP2C9 (0.56) | POLBCYP2C9KDM4EALDH1A1MAPT | |
| SCHEMBL1419493 | 0.82 | CYP2C9 (0.56) | POLBCYP2C9KDM4EALDH1A1MAPT | |
| SCHEMBL1985139 | 0.80 | CYP2C9 (0.32) | CYP2C9 | |
| SCHEMBL2671871 | 0.79 | CYP2C9 (0.42) | ADORA2AADORA2BADORA1POLBCYP2C9 | |
| SCHEMBL10136090 | 0.79 | ADORA2A (0.40) | ADORA2AADORA2BADORA1POLBCYP2C9 | |
| SCHEMBL15607 | 0.79 | GRIK1 (0.42) | KDM4EALDH1A1LMNAGRIK1SLC16A1 | |
| SCHEMBL4072774 | 0.79 | ADORA2A (0.40) | ADORA2AADORA2BADORA1POLBCYP2C9 | |
| SCHEMBL10167752 | 0.79 | CYP2C9 (0.42) | ADORA2AADORA2BADORA1POLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2916832-B1 | A PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LTD (IN) | 2019-01-16 | — | — | EP | disclosed |
| US-10023885-B2 | Process for the preparation of pregabalin | HIKAL LIMITED (IN) | 2018-07-17 | — | — | US | disclosed |
| US-20150344919-A1 | PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LIMITED (IN) | 2015-12-03 | — | — | US | disclosed |
| EP-2916832-A2 | A PROCESS FOR THE PREPARATION OF PREGABALIN | Hikal Limited (IN) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014072785-A2 | A PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LIMITED (IN) | 2014-05-15 | — | — | WO | disclosed |
| US-7250433-B2 | Tetrazole and oxadiazolone substituted β-amino acid derivatives | WARNER LAMBERT COMPANY LLC (US) | 2007-07-31 | — | — | US | disclosed |
| US-7030267-B2 | Cycloproply β-amino acid derivatives | WARNER-LAMBERT COMPANY, LLC (US) | 2006-04-18 | — | — | US | disclosed |
| EP-1603890-A1 | TETRAZOLE AND OXADIAZOLONE SUBSTITUTED &bgr;-AMINO ACID DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1592661-A2 | CYCLOPROPYL BETA-AMINO ACID DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-20050014804-A1 | Tetrazole and oxadiazolone substituted beta-amino acid derivatives | BARTA NANCY SUE (US) | 2005-01-20 | — | — | US | disclosed |
| WO-2004078734-A1 | TETRAZOLE AND OXADIAZOLONE SUBSTITUTED β-AMINO ACID DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2004-09-16 | — | — | WO | disclosed |
| WO-2004065361-A2 | CYCLOPROPYL BETA-AMINO ACID DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-05 | — | — | WO | disclosed |
| US-20040147608-A1 | Cyclopropyl beta-amino acid derivatives | SCHWARZ JACOB BRADLEY (US) | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147608-A1 | Cyclopropyl beta-amino acid derivatives | CACNA1S, CACNA1D, CACNA1B | ADORA2A 203/4885ADORA2B 162/4885ADORA1 115/4885 |
| US-10023885-B2 | Process for the preparation of pregabalin | CHRNA6, CHRNA9, ADH5 | ADORA2A 2906/4885ADORA2B 1247/4885ADORA1 2187/4885 |
| US-20050014804-A1 | Tetrazole and oxadiazolone substituted beta-amino acid derivatives | GLRA2, CACNG5, GLRB | ADORA2A 170/4885ADORA2B 129/4885ADORA1 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.