SCHEMBL564520

SCHEMBL564520

Nc1ccc(Oc2ccc(N)c(O)c2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.58
TDP1 Q9NUW8 2/20 0.58
CYP3A4 P08684 2/20 0.58
TSHR P16473 1/20 0.58
MAPT P10636 4/20 0.57
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
SMN1; SMN2 Q16637 3/20 0.57
GAA P10253 2/20 0.57
MITF O75030 1/20 0.57
GFER P55789 1/20 0.57
NLRP1 Q9C000 1/20 0.57
NOD2 Q9HC29 1/20 0.57
NR4A1 P22736 1/20 0.52
MAOA P21397 2/20 0.50
MMP2 P08253 1/20 0.49
MMP14 P50281 1/20 0.49
TEAD4 Q15561 1/20 0.48
MAOB P27338 1/20 0.48
PARP10 Q53GL7 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19809245 0.94 NR4A1 (0.58) ALDH1A1TDP1CYP3A4TSHRMAPT
SCHEMBL716944 0.94 NR4A1 (0.58) ALDH1A1TDP1CYP3A4TSHRMAPT
SCHEMBL30040301 0.91 NR4A1 (0.61) ALDH1A1TDP1CYP3A4TSHRMAPT
SCHEMBL436522 0.91 NR4A1 (0.61) ALDH1A1TDP1CYP3A4TSHRMAPT
SCHEMBL563890 0.89 MEN1 (0.61) ALDH1A1TDP1CYP3A4TSHRMAPT
Hydrochloric Acid SCHEMBL10770715 0.89 NR4A1 (0.58) ALDH1A1TDP1CYP3A4TSHRMAPT
SCHEMBL1348470 0.88 CYP3A4 (0.58) ALDH1A1TDP1CYP3A4TSHRMAPT
SCHEMBL27510157 0.87 NR4A1 (0.56) ALDH1A1TDP1CYP3A4TSHRMAPT
SCHEMBL564952 0.86 LTA4H (0.59) ALDH1A1CYP3A4TSHRMAPTMEN1
SCHEMBL30233344 0.86 LTA4H (0.59) ALDH1A1CYP3A4TSHRMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8674029-B2 Method of preparing stabilized polymeric systems using polymeric peroxides Sunocs LLC (US) 2014-03-18 US disclosed
US-20120035307-A1 PROCESS FOR MAKING STABLIZED POLYMERIC SYSTEMS WITH NANOSTRUCTURES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-20120035315-A1 METHOD OF PREPARING STABLIZED POLYMERIC SYSTEMS USING POLYMERIC PEROXIDES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-7498467-B2 Antioxidant and bisaminophenol derivative IDEMITSU KOSAN CO., LTD. (JP) 2009-03-03 US disclosed
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN CO., LTD. (JP) 2008-07-03 US disclosed
US-20060208227-A1 Antioxidant and bisaminophenol derivative IDEMITSU LOSAN CO., LTD (JP) 2006-09-21 US disclosed
EP-1612254-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN COMPANY LIMITED (JP) 2006-01-04 EP disclosed
EP-0431971-B1 Photosensitive composition and resin-encapsulated semiconductor device TOSHIBA KK (JP) 1995-07-19 EP disclosed
EP-0431971-A2 Photosensitive composition and resin-encapsulated semiconductor device KABUSHIKI KAISHA TOSHIBA (JP) 1991-06-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE CBR1, CBR3, HMOX1 ALDH1A1 204/4885TDP1 1337/4885CYP3A4 360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.