Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | KCNK5 | O95279 | 1/20 | 0.52 |
| ▸ | KCNK17 | Q96T54 | 1/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6357659 | 0.90 | TP53 (0.56) | HPGDALDH1A1MAPK8L3MBTL1TDP1 | |
| SCHEMBL6362508 | 0.89 | HPGD (0.50) | HPGDALDH1A1MAPK8L3MBTL1TDP1 | |
| SCHEMBL6356836 | 0.84 | KDM4E (0.52) | HPGDALDH1A1L3MBTL1TP53 | |
| SCHEMBL15686616 | 0.83 | HPGD (0.64) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| SCHEMBL5645147 | 0.83 | AKR1B1 (0.57) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| SCHEMBL5644455 | 0.83 | HPGD (0.52) | HPGDALDH1A1CYP1A2KMT2ANPC1 | |
| SCHEMBL3460904 | 0.80 | EPHX2 (0.57) | KCNA5AKR1B1HPGDALDH1A1MEN1 | |
| SCHEMBL15686619 | 0.80 | KMT2A (0.70) | HPGDALDH1A1L3MBTL1CYP1A2KMT2A | |
| SCHEMBL6361750 | 0.80 | P2RX7 (0.52) | HPGDALDH1A1MAPK8L3MBTL1TDP1 | |
| SCHEMBL23675392 | 0.78 | TAS1R3 (0.62) | KCNA5AKR1B1GSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |