Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.44 |
| ▸ | SDHB | P21912 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | STAT3 | P40763 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | STAT1 | P42224 | 2/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18963 | 0.92 | NPSR1 (0.49) | NPSR1SDHBRAB9ATP53HPGD | |
| SCHEMBL17590 | 0.79 | KMO (0.59) | NPSR1SDHBRAB9ATP53HPGD | |
| SCHEMBL28146826 | 0.79 | NPC1 (0.45) | NPSR1SDHBRAB9ATP53HPGD | |
| SCHEMBL2410945 | 0.76 | RAB9A (0.56) | NPSR1SDHBRAB9ATP53HPGD | |
| SCHEMBL16538788 | 0.76 | KCNH2 (0.53) | NPSR1SDHBRAB9ATP53HPGD | |
| SCHEMBL4447801 | 0.76 | BPTF (0.54) | NPSR1SDHBRAB9ATP53HPGD | |
| SCHEMBL3572760 | 0.75 | HSP90AA1 (0.57) | RAB9ALMNAPOLBALDH1A1PTGS2 | |
| SCHEMBL2415488 | 0.75 | KDM4E (0.49) | NPSR1SDHBRAB9ATP53HPGD | |
| SCHEMBL5593337 | 0.74 | SDHB (0.72) | NPSR1SDHBRAB9ATP53HPGD | |
| SCHEMBL4071288 | 0.73 | KMO (0.51) | LMNAKMT2AHTTMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100349856-C | Propionic acid derivatives and their use as hPPAR activators | SMITHKLINE BEECHAM CORP (US) | 2007-11-21 | — | — | CN | disclosed |
| US-7199239-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-20060074111-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2006-04-06 | — | — | US | disclosed |
| CN-1675168-A | Propionic acid derivatives and their use as hPPARs activators | SMITHKLINE BEECHAM CORP (US) | 2005-09-28 | — | — | CN | disclosed |
| EP-1513795-A2 | PROPIONIC ACID DERIVATIVES AND THEIR USE AS HPPARS ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-16 | — | — | EP | disclosed |
| WO-2004000762-A2 | PROPIONIC ACID DERIVATIVES AND THEIR USE AS HPPARS ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074111-A1 | Chemical compounds | HDAC3, HAT1, H1-3 | NPSR1 1174/4885SDHB 2120/4885RAB9A 2573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.