Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
| ▸ | TRPV3 | Q8NET8 | 8/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4451357 | 0.84 | CTSS (0.46) | TRPV3GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL3564206 | 0.83 | KDM4E (0.47) | TOP1GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL3560816 | 0.83 | RAD51 (0.45) | TRPV3TOP1GABRA1GABRG2GABRB3 | |
| SCHEMBL4787 | 0.82 | CTSS (0.60) | — | |
| SCHEMBL28345610 | 0.81 | KIF11 (0.65) | SCN9AKIF11TRPV3TOP1 | |
| SCHEMBL30755399 | 0.79 | TRPV3 (0.47) | SCN9AKIF11TRPV3TOP1 | |
| SCHEMBL22337449 | 0.79 | NOTUM (0.47) | SCN9AKIF11TRPV3GABRA1GABRG2 | |
| SCHEMBL8612884 | 0.79 | SCN9A (0.47) | SCN9AKIF11TRPV3TOP1 | |
| SCHEMBL3560374 | 0.79 | PTPN1 (0.39) | KIF11TRPV3TOP1 | |
| SCHEMBL15571062 | 0.79 | ALDH1A1 (0.43) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100349856-C | Propionic acid derivatives and their use as hPPAR activators | SMITHKLINE BEECHAM CORP (US) | 2007-11-21 | — | — | CN | disclosed |
| US-7199239-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199239-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199239-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-20060074111-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2006-04-06 | — | — | US | disclosed |
| CN-1675168-A | Propionic acid derivatives and their use as hPPARs activators | SMITHKLINE BEECHAM CORP (US) | 2005-09-28 | — | — | CN | disclosed |
| EP-1513795-A2 | PROPIONIC ACID DERIVATIVES AND THEIR USE AS HPPARS ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-16 | — | — | EP | disclosed |
| WO-2004000762-A2 | PROPIONIC ACID DERIVATIVES AND THEIR USE AS HPPARS ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074111-A1 | Chemical compounds | HDAC3, HAT1, H1-3 | SCN9A 939/4885KIF11 2312/4885TRPV3 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.