Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31241118 | 0.78 | RAB9A (0.66) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1993637 | 0.78 | DEGS1 (0.64) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5651536 | 0.78 | SMN1; SMN2 (0.51) | LMNAKMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL944219 | 0.76 | CYP1A2 (0.63) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7121725 | 0.76 | KMT2A (0.70) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27647737 | 0.76 | MEN1 (0.60) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL12411456 | 0.75 | L3MBTL1 (0.52) | LMNAKMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL27427372 | 0.74 | SMN1; SMN2 (0.50) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17963904 | 0.74 | GAA (0.47) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL31241073 | 0.74 | RAB9A (0.65) | LMNAKMT2ASMN1; SMN2RAB9AMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |