Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31241118 | 0.83 | RAB9A (0.66) | SMN1; SMN2RAB9AMAPK10ADORA1MEN1 | |
| SCHEMBL10996517 | 0.81 | ADORA1 (0.47) | SMN1; SMN2RAB9AMAPK10ADORA1MEN1 | |
| SCHEMBL12411456 | 0.80 | L3MBTL1 (0.52) | SMN1; SMN2RAB9AMAPK10ADORA1KMT2A | |
| SCHEMBL1993637 | 0.80 | DEGS1 (0.64) | SMN1; SMN2RAB9AMAPK10ADORA1MEN1 | |
| SCHEMBL27427372 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AMAPK10ADORA1MEN1 | |
| SCHEMBL31241073 | 0.79 | RAB9A (0.65) | SMN1; SMN2RAB9AMAPK10ADORA1KMT2A | |
| SCHEMBL5651367 | 0.78 | LMNA (0.58) | SMN1; SMN2RAB9AMAPK10ADORA1MEN1 | |
| SCHEMBL1994251 | 0.76 | CNR1 (0.51) | SMN1; SMN2RAB9AKMT2ALMNAL3MBTL1 | |
| SCHEMBL22610228 | 0.76 | LMNA (0.58) | SMN1; SMN2RAB9AADORA1KMT2ALMNA | |
| SCHEMBL7237360 | 0.76 | ADORA1 (0.54) | SMN1; SMN2RAB9AMAPK10ADORA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |