Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651499 | 0.94 | MDM2 (0.51) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5650191 | 0.92 | ALDH1A1 (0.47) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5648462 | 0.90 | MAPK8 (0.51) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5653013 | 0.90 | GABRA1 (0.47) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5652931 | 0.89 | ACACB (0.53) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5651409 | 0.89 | ALDH1A1 (0.45) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5653004 | 0.87 | ALDH1A1 (0.41) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2958441 | 0.86 | ALDH1A1 (0.55) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5648783 | 0.85 | LMNA (0.45) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5648142 | 0.84 | ALDH1A1 (0.42) | ALDH1A1MAPK1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176215-B2 | Bicyclic oxopyridine and oxopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2007-02-13 | — | — | US | disclosed |
| US-20040254200-A1 | Bicyclic oxopyridine and oxopyrimidine derivatives | UCB PHARMA S.A. (BE) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254200-A1 | Bicyclic oxopyridine and oxopyrimidine derivatives | MAPK1, ALK, NAT1 | ALDH1A1 1498/4885MAPK1 1/4885MEN1 4697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.