Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17201504 | 0.85 | IKBKB (0.48) | IKBKBALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL5196243 | 0.84 | KDM4E (0.61) | CYP19A1CYP11B1CYP11B2IKBKBALDH1A1 | |
| SCHEMBL14367853 | 0.83 | MKNK1 (0.55) | ALDH1A1MKNK1MKNK2ABCB1CYP3A4 | |
| Hydrochloric Acid SCHEMBL5653571 | 0.82 | MKNK1 (0.54) | ALDH1A1MKNK1MKNK2ABCB1CYP3A4 | |
| SCHEMBL24131787 | 0.77 | MAPT (0.55) | ALDH1A1KDM4EMAPTLMNAPOLB | |
| SCHEMBL5652586 | 0.75 | PTPN1 (0.52) | CYP19A1CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL206570 | 0.75 | NPC1 (0.61) | ALDH1A1KDM4EMAPTLMNAPOLB | |
| SCHEMBL17201697 | 0.74 | ALDH1A1 (0.61) | CYP19A1CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL7084334 | 0.74 | CYP11B1 (0.64) | CYP19A1CYP11B1CYP11B2ALDH1A1LMNA | |
| SCHEMBL4967106 | 0.74 | NR4A2 (0.60) | CYP19A1CYP11B1CYP11B2MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270458-A1 | Nicotinic Acetylcholine Receptor Ligands | ASTRAZENECA AB (SE) | 2007-11-22 | — | — | US | disclosed |
| US-20070270458-A1 | Nicotinic Acetylcholine Receptor Ligands | ASTRAZENECA AB (SE) | 2007-11-22 | — | — | US | disclosed |
| US-20070270458-A1 | Nicotinic Acetylcholine Receptor Ligands | ASTRAZENECA AB (SE) | 2007-11-22 | — | — | US | disclosed |
| CN-1914201-A | Nicotinic acetylcholine receptor ligands | ASTRAZENECA AB (SE) | 2007-02-14 | — | — | CN | disclosed |
| EP-1699786-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061494-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270458-A1 | Nicotinic Acetylcholine Receptor Ligands | CHRNA2, CHRNA1, CHRNA6 | CYP19A1 2663/4885CYP11B1 2759/4885CYP11B2 2570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.