Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.64 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.64 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 4/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379809 | 0.82 | KMO (0.62) | CYP11B1CYP11B2ABL1ALDH1A1BCR | |
| SCHEMBL18355729 | 0.81 | MKNK1 (0.76) | CYP11B1CYP11B2CYP19A1ABL1SLC2A1 | |
| SCHEMBL2127568 | 0.80 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1ABL1SLC2A1 | |
| SCHEMBL2143386 | 0.80 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1ABL1SLC2A1 | |
| SCHEMBL1399775 | 0.80 | CYP19A1 (0.74) | CYP11B1CYP11B2CYP19A1ABL1SLC2A1 | |
| SCHEMBL2345607 | 0.79 | CYP19A1 (0.74) | CYP11B1CYP11B2CYP19A1ABL1SLC2A1 | |
| SCHEMBL12365981 | 0.78 | CYP11B1 (0.57) | CYP11B1CYP11B2CYP19A1ABL1SLC2A1 | |
| SCHEMBL3511516 | 0.78 | CYP19A1 (0.68) | CYP11B1CYP11B2CYP19A1ABL1SLC2A1 | |
| SCHEMBL10028698 | 0.78 | CYP19A1 (0.68) | CYP11B1CYP11B2CYP19A1ABL1SLC2A1 | |
| SCHEMBL4509922 | 0.78 | CYP11B2 (1.00) | CYP11B1CYP11B2CYP19A1ABL1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030105139-A1 | Indole derivatives as 5-HT receptor antagonist | SMITHKLINE BEECHAM P.L.C. | 2003-06-05 | — | — | US | disclosed |
| US-6235758-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-22 | — | — | US | disclosed |
| EP-0808312-B1 | INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-5990133-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY OR DEPRESSION | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105139-A1 | Indole derivatives as 5-HT receptor antagonist | HTR5A, HTR2C, HTR1A | CYP11B1 929/4885CYP11B2 710/4885CYP19A1 2384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.