Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1919879 | 0.75 | CDC7 (0.54) | ALDH1A1CYP11B1CYP11B2CYP19A1HDAC3 | |
| SCHEMBL5652096 | 0.75 | CYP19A1 (0.49) | ALDH1A1CYP11B1CYP11B2CYP19A1HDAC3 | |
| SCHEMBL3904612 | 0.75 | PTPN1 (0.60) | PTPN1 | |
| SCHEMBL27691396 | 0.70 | GABRA1 (0.60) | ALDH1A1CYP11B1CYP11B2CYP19A1CFTR | |
| SCHEMBL5196243 | 0.70 | KDM4E (0.61) | ALDH1A1CYP11B1CYP11B2CYP19A1CFTR | |
| SCHEMBL28699640 | 0.69 | CFTR (0.54) | ALDH1A1CYP11B1CYP11B2CYP19A1CFTR | |
| SCHEMBL18195379 | 0.69 | ALDH1A1 (0.54) | ALDH1A1CYP11B1CYP11B2CYP19A1HDAC1 | |
| SCHEMBL14237794 | 0.69 | CYP1A2 (0.57) | ALDH1A1CYP11B1CYP11B2CYP19A1CYP3A4 | |
| SCHEMBL17201697 | 0.69 | ALDH1A1 (0.61) | ALDH1A1CYP11B1CYP11B2CYP19A1HDAC3 | |
| SCHEMBL9827009 | 0.69 | TRPM8 (0.51) | PTPN1ALDH1A1HPGDMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270458-A1 | Nicotinic Acetylcholine Receptor Ligands | ASTRAZENECA AB (SE) | 2007-11-22 | — | — | US | disclosed |
| US-20070270458-A1 | Nicotinic Acetylcholine Receptor Ligands | ASTRAZENECA AB (SE) | 2007-11-22 | — | — | US | disclosed |
| CN-1914201-A | Nicotinic acetylcholine receptor ligands | ASTRAZENECA AB (SE) | 2007-02-14 | — | — | CN | disclosed |
| EP-1699786-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061494-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270458-A1 | Nicotinic Acetylcholine Receptor Ligands | CHRNA2, CHRNA1, CHRNA6 | PTPN1 2063/4885ALDH1A1 755/4885CYP11B1 2759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.