Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5650346 | 0.79 | IDO1 (0.49) | KDM4EMEN1KMT2APOLB | |
| SCHEMBL5921916 | 0.79 | RAB9A (0.56) | MEN1KMT2ARAB9AALOX15HSD17B10 | |
| SCHEMBL5650853 | 0.77 | RAB9A (0.41) | MEN1KMT2ARAB9AALOX15HSD17B10 | |
| SCHEMBL21186229 | 0.77 | KMT2A (0.59) | KDM4EMEN1KMT2ARAB9AHSD17B10 | |
| SCHEMBL26128621 | 0.75 | DHFR (0.44) | MEN1KMT2ARAB9AALOX15HSD17B10 | |
| SCHEMBL3365264 | 0.75 | MEN1 (0.60) | KDM4EMEN1KMT2A | |
| SCHEMBL5650279 | 0.74 | NPC1 (0.44) | KDM4EMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL4415791 | 0.74 | MAOB (0.63) | KDM4EMEN1KMT2AGRM5 | |
| SCHEMBL5321349 | 0.73 | ALOX15 (0.53) | KDM4ERAB9AALOX15HSD17B10ALDH1A1 | |
| SCHEMBL4638512 | 0.72 | MAOB (0.50) | MEN1KMT2ARAB9AALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |