Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653757 | 0.89 | PPARD (0.41) | PPARDPTGER4KDM4EALDH1A1HPGD | |
| SCHEMBL6017359 | 0.85 | PKM (0.42) | PKMPPARDMAPTPTGER4ALDH1A1 | |
| SCHEMBL6017372 | 0.85 | PKM (0.43) | PKMPPARDPRMT5TRPV1 | |
| SCHEMBL6065143 | 0.82 | PKM (0.42) | PKMPPARDMAPTPTGER4ALDH1A1 | |
| SCHEMBL6017323 | 0.81 | PKM (0.45) | PKMPPARDMAPTPRMT5KDM4E | |
| SCHEMBL9662589 | 0.80 | PKM (0.60) | PKMMAPTKDM4EALDH1A1POLB | |
| SCHEMBL6064759 | 0.80 | PKM (0.40) | PKMPPARDMAPTPTGER4PRMT5 | |
| SCHEMBL6065162 | 0.80 | PKM (0.40) | PKMPPARDMAPTPTGER4ALDH1A1 | |
| SCHEMBL6017361 | 0.78 | PKM (0.42) | PKMPPARDMAPT | |
| SCHEMBL6065368 | 0.78 | PKM (0.41) | PKMMAPTALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |