Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 1/20 | 0.41 |
| ▸ | ADH1C | P00326 | 1/20 | 0.41 |
| ▸ | ADH1A | P07327 | 1/20 | 0.41 |
| ▸ | ADH4 | P08319 | 1/20 | 0.41 |
| ▸ | ADH7 | P40394 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 6/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801233 | 0.98 | ADH1B (0.38) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL2281448 | 0.90 | SAT1 (0.38) | TDP1KMT2A | |
| SCHEMBL13483172 | 0.81 | HTT (0.39) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL1775544 | 0.81 | ADH1B (0.38) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL23224291 | 0.79 | THRB (0.43) | — | |
| SCHEMBL4670064 | 0.78 | SIGMAR1 (0.44) | EPHX1KMT2A | |
| SCHEMBL12801292 | 0.78 | SLC6A2 (0.34) | KMT2A | |
| SCHEMBL172616 | 0.77 | ADH1B (0.45) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL9205347 | 0.76 | CYP1A2 (0.36) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL4673810 | 0.76 | SIGMAR1 (0.42) | EPHX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511745-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2006-11-15 | — | — | EP | disclosed |
| US-7109233-B2 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1532115-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2006-01-11 | — | — | EP | disclosed |
| US-20050256100-A1 | Protease inhibitors | JEONG JAE U | 2005-11-17 | — | — | US | disclosed |
| US-20050234038-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-10-20 | — | — | US | disclosed |
| EP-1532115-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1511745-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003104257-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-18 | — | — | WO | disclosed |
| WO-2003097593-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234038-A1 | Protease inhibitors | SPINT2, CTRL, PRSS1 | ADH1B 3736/4885ADH1C 4097/4885ADH1A 3516/4885 |
| US-20050256100-A1 | Protease inhibitors | SPINT2, PRSS1, ADAM17 | ADH1B 3154/4885ADH1C 3200/4885ADH1A 2505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.