Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.55 |
| ▸ | CHUK | O15111 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29787086 | 0.80 | CHUK (0.50) | IMPDH2CHUKLMNACYP1A2CYP3A4 | |
| SCHEMBL2243252 | 0.80 | CHUK (0.50) | IMPDH2CHUKLMNACYP1A2CYP3A4 | |
| SCHEMBL5659114 | 0.78 | LMNA (0.55) | IMPDH2CHUKLMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL2240661 | 0.78 | CHUK (0.49) | IMPDH2CHUKLMNACYP1A2CYP3A4 | |
| SCHEMBL3326564 | 0.76 | PRKCH (0.55) | IMPDH2LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30905977 | 0.74 | NR4A2 (0.44) | IMPDH2LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27932280 | 0.73 | IMPDH2 (0.50) | IMPDH2CHUKLMNACYP1A2CYP3A4 | |
| SCHEMBL5656993 | 0.73 | CYP1A2 (0.49) | IMPDH2CHUKLMNACYP1A2CYP3A4 | |
| SCHEMBL30218963 | 0.73 | CYP1A2 (0.49) | IMPDH2CHUKLMNACYP1A2CYP3A4 | |
| SCHEMBL5659020 | 0.73 | CYP1A2 (0.51) | IMPDH2CHUKLMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227054-B | ROCK kinase inhibitors | 切尔韦洛治疗有限责任公司 | 2025-04-11 | — | — | CN | disclosed |
| EP-3877364-B1 | ROCK KINASE INHIBITORS | Cervello Therapeutics LLC (US) | 2024-08-21 | — | — | EP | disclosed |
| US-11912719-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912719-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912719-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20220119406-A1 | SUBSTITUTED ISOQUINOLINES AS ROCK KINASE INHIBITORS | Cervello Therapeutics LLC (US) | 2022-04-21 | — | — | US | disclosed |
| US-20220119406-A1 | SUBSTITUTED ISOQUINOLINES AS ROCK KINASE INHIBITORS | Cervello Therapeutics LLC (US) | 2022-04-21 | — | — | US | disclosed |
| US-11248004-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2022-02-15 | — | — | US | disclosed |
| US-11248004-B2 | Substituted isoquinolines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2022-02-15 | — | — | US | disclosed |
| EP-3877364-A1 | ROCK KINASE INHIBITORS | Cervello Therapeutics, LLC (US) | 2021-09-15 | — | — | EP | disclosed |
| CN-113227054-A | ROCK kinase inhibitors | 切尔韦洛治疗有限责任公司 | 2021-08-06 | — | — | CN | disclosed |
| US-20200262844-A1 | ROCK KINASE INHIBITORS | CERVELLO THERAPEUTICS, LLC. | 2020-08-20 | — | — | US | disclosed |
| US-20200262844-A1 | ROCK KINASE INHIBITORS | CERVELLO THERAPEUTICS, LLC. | 2020-08-20 | — | — | US | disclosed |
| US-10745381-B2 | Substituted isoquinolines and phthalazines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-20200140412-A1 | ROCK KINASE INHIBITORS | CERVELLO THERAPEUTICS, LLC. | 2020-05-07 | — | — | US | disclosed |
| US-7285563-B2 | Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745381-B2 | Substituted isoquinolines and phthalazines as rock kinase inhibitors | ROCK1, ROCK2, CIT | IMPDH2 695/4885CHUK 275/4885LMNA 2467/4885 |
| US-11248004-B2 | Substituted isoquinolines as rock kinase inhibitors | ROCK1, ROCK2, CIT | IMPDH2 619/4885CHUK 261/4885LMNA 1820/4885 |
| US-11912719-B2 | Substituted isoquinolines as rock kinase inhibitors | ROCK1, ROCK2, CIT | IMPDH2 619/4885CHUK 261/4885LMNA 1820/4885 |
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | ARRB1, OPRL1, CNR1 | IMPDH2 3396/4885CHUK 581/4885LMNA 2921/4885 |
| US-20200140412-A1 | ROCK KINASE INHIBITORS | ROCK1, ROCK2, RHOA | IMPDH2 2616/4885CHUK 244/4885LMNA 1600/4885 |
| US-20200262844-A1 | ROCK KINASE INHIBITORS | ROCK1, ROCK2, RHOA | IMPDH2 2616/4885CHUK 244/4885LMNA 1600/4885 |
| US-20220119406-A1 | SUBSTITUTED ISOQUINOLINES AS ROCK KINASE INHIBITORS | ROCK1, ROCK2, CIT | IMPDH2 619/4885CHUK 261/4885LMNA 1820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.