Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.33 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658335 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL5660200 | 0.78 | KMT2A (0.51) | KDM4EALDH1A1ALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL186124 | 0.76 | MAPT (0.59) | KDM4EALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL5660559 | 0.73 | MAPT (0.45) | KDM4EALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL18531914 | 0.72 | LMNA (0.41) | KDM4EALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL185428 | 0.72 | KDM4E (0.52) | KDM4EALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL15514113 | 0.71 | HCAR3 (0.50) | KDM4EALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL5657166 | 0.71 | HCAR3 (0.40) | KDM4EALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL4842036 | 0.70 | SMN1; SMN2 (0.63) | KDM4EALOX15MAPK1SMN1; SMN2MEN1 | |
| SCHEMBL31690348 | 0.69 | MEN1 (0.38) | ALDH1A1ALOX15HSD17B10MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |