Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658255 | 0.77 | KMT2A (0.61) | KDM4EALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL15514113 | 0.74 | HCAR3 (0.50) | HCAR3KDM4EHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL5660811 | 0.73 | GAA (0.60) | KDM4EALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL5658844 | 0.73 | CXCR1 (0.53) | KDM4EALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL5660559 | 0.72 | MAPT (0.45) | HCAR3KDM4EHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL5658335 | 0.71 | KDM4E (0.50) | HCAR3KDM4EHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL186124 | 0.71 | MAPT (0.59) | HCAR3KDM4EHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL5657170 | 0.71 | KDM4E (0.46) | HCAR3KDM4EHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL5659943 | 0.71 | KMT2A (0.52) | HCAR3HSD17B10ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL5660210 | 0.71 | SMN1; SMN2 (0.55) | KDM4EALDH1A1MAPTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |