Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5657170 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL5660200 | 0.82 | KMT2A (0.51) | KDM4EALDH1A1HSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL186124 | 0.80 | MAPT (0.59) | KDM4EALDH1A1HSD17B10ALOX15MAPT | |
| SCHEMBL5660559 | 0.77 | MAPT (0.45) | KDM4EALDH1A1HSD17B10ALOX15MAPT | |
| SCHEMBL6538720 | 0.74 | SMN1; SMN2 (0.68) | SMN1; SMN2KEAP1NFE2L2SRD5A2PLA2G4B | |
| SCHEMBL15514113 | 0.71 | HCAR3 (0.50) | KDM4EALDH1A1HSD17B10ALOX15MAPT | |
| SCHEMBL26704132 | 0.71 | ALDH1A1 (0.44) | KDM4EALDH1A1HSD17B10ALOX15MAPT | |
| SCHEMBL15505042 | 0.71 | XDH (0.50) | KDM4EALDH1A1HSD17B10ALOX15MAPT | |
| SCHEMBL185428 | 0.71 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10ALOX15MAPT | |
| SCHEMBL23405915 | 0.71 | KEAP1 (0.45) | KDM4EHSD17B10SMN1; SMN2POLBKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |