Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 10/20 | 0.73 |
| ▸ | DRD2 | P14416 | 9/20 | 0.73 |
| ▸ | DRD1 | P21728 | 6/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CCND1 | P24385 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5655844 | 0.92 | DRD3 (0.76) | DRD3DRD2DRD1ADRA1AADRA1B | |
| SCHEMBL5656983 | 0.91 | DRD3 (0.74) | DRD3DRD2DRD1ADRA1AADRA1B | |
| SCHEMBL5656296 | 0.90 | DRD3 (0.76) | DRD3DRD2DRD1ADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL28739470 | 0.89 | DRD3 (0.74) | DRD3DRD2DRD1ADRA1AADRA1B | |
| SCHEMBL5656309 | 0.82 | KCNH2 (0.67) | DRD3DRD2DRD1DRD4HTR2A | |
| SCHEMBL9785952 | 0.82 | DRD2 (0.76) | DRD3DRD2DRD1MEN1KMT2A | |
| SCHEMBL5657064 | 0.79 | MAPT (0.64) | DRD3DRD2DRD1KDM4ELMNA | |
| SCHEMBL11273863 | 0.78 | KDM4E (0.70) | DRD3DRD2DRD1ADRA1AADRA1B | |
| SCHEMBL3194731 | 0.78 | KDM4E (0.70) | DRD3DRD2DRD1ADRA1AADRA1B | |
| SCHEMBL7328095 | 0.77 | KDM4E (0.69) | DRD3DRD2DRD1ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223765-B2 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2007-05-29 | — | — | US | claimed |
| US-20060148815-A1 | 4-Phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2006-07-06 | — | — | US | claimed |
| US-7223765-B2 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2007-05-29 | — | — | US | disclosed |
| CN-1803784-A | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | LUNDBECK CO AS H (DK) | 2006-07-19 | — | — | CN | disclosed |
| US-7074796-B2 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2006-07-11 | — | — | US | disclosed |
| US-20060148815-A1 | 4-Phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2006-07-06 | — | — | US | disclosed |
| CN-1244577-C | 4-phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridinyl derivatives | LUNDBECK & CO AS H (DK) | 2006-03-08 | — | — | CN | disclosed |
| EP-1464641-A1 | 4-Phenyl-piperazinyl, -piperidinyl and tetrahydropyridyl derivatives as dopamine D4 antagonists | H. Lundbeck A/S (DK) | 2004-10-06 | — | — | EP | disclosed |
| EP-1246817-B1 | 4-PHENYL-1-PIPERAZINYL, -PIPERIDINYL AND -TETRAHYDROPYRIDYL DERIVATIVES | LUNDBECK & CO AS H (DK) | 2004-06-23 | — | — | EP | disclosed |
| CN-1434819-A | 4-phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridinyl derivatives | LUNDBECK & CO AS H (DK) | 2003-08-06 | — | — | CN | disclosed |
| US-20030027832-A1 | 4-Phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2003-02-06 | — | — | US | disclosed |
| EP-1246817-A1 | 4-PHENYL-1-PIPERAZINYL, -PIPERIDINYL AND -TETRAHYDROPYRIDYL DERIVATIVES | H. Lundbeck A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049679-A1 | 4-PHENYL-1-PIPERAZINYL, -PIPERIDINYL AND -TETRAHYDROPYRIDYL DERIVATIVES | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148815-A1 | 4-Phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridyl derivatives | OPRD1, VDR, GPR4 | DRD3 22/4885DRD2 27/4885DRD1 56/4885 |
| US-20030027832-A1 | 4-Phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | OPRD1, DRD3, DRD2 | DRD3 2/4885DRD2 3/4885DRD1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.