Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.35 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072407 | 0.96 | CYP11B1 (0.40) | CYP11B1CYP11B2TSHRSMN1; SMN2NPC1 | |
| SCHEMBL17610579 | 0.78 | NOTUM (0.48) | SMN1; SMN2RAB9AMAPT | |
| SCHEMBL27864869 | 0.77 | KIF11 (0.34) | MAPTALDH1A1KIF11 | |
| SCHEMBL28592057 | 0.76 | MAPT (0.47) | TSHRSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL3149937 | 0.73 | PRKAB2 (0.36) | SMN1; SMN2RAB9AMAPT | |
| SCHEMBL3141306 | 0.73 | DYRK1A (0.48) | SMN1; SMN2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL28663639 | 0.73 | CYP11B1 (0.61) | CYP11B1CYP11B2TSHRSMN1; SMN2NPC1 | |
| SCHEMBL9845507 | 0.72 | CYP11B1 (0.61) | CYP11B1CYP11B2TSHRSMN1; SMN2NPC1 | |
| SCHEMBL2794744 | 0.72 | HTR2A (0.37) | CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8077911 | 0.72 | NPC1 (0.36) | CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179825-B2 | Retinoic acid mimetic anilides | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-20 | — | — | US | claimed |