Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 6/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313264 | 0.91 | MAPT (0.52) | MAPTKDM4EALDH1A1LTA4HACHE | |
| SCHEMBL5310940 | 0.85 | LTA4H (0.66) | MAPTKDM4EALDH1A1LTA4HMEN1 | |
| SCHEMBL5312752 | 0.81 | LTA4H (0.56) | MAPTKDM4EALDH1A1TP53LTA4H | |
| SCHEMBL5312545 | 0.77 | LTA4H (0.77) | LTA4H | |
| SCHEMBL5385123 | 0.77 | LTA4H (0.54) | MAPTKDM4EALDH1A1TP53LTA4H | |
| SCHEMBL4361298 | 0.75 | MAPT (0.77) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL5392156 | 0.73 | MAPT (0.77) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL5312334 | 0.72 | LTA4H (0.85) | LTA4H | |
| SCHEMBL20249538 | 0.71 | LTA4H (0.63) | MAPTLTA4HATMACHERAB9A | |
| SCHEMBL13052122 | 0.70 | ACHE (0.66) | MAPTKDM4EALDH1A1ACHENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155727-A1 | Amide inhibitors of leukotriene A4 hydrolase | SCHERING AKTIENGESSELLSCHAFT (DE) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155727-A1 | Amide inhibitors of leukotriene A4 hydrolase | LTA4H, LTB4R, LTC4S | MAPT 4374/4885KDM4E 1019/4885ALDH1A1 1337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.