Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15863438 | 0.81 | KCNH2 (0.49) | ALDH1A1KCNH2ALOX15MTNR1AMTNR1B | |
| SCHEMBL9808291 | 0.80 | KCNH2 (0.57) | ALDH1A1KCNH2ALOX15LMNA | |
| SCHEMBL27545848 | 0.80 | ALDH1A1 (0.48) | ALDH1A1 | |
| SCHEMBL8315005 | 0.80 | KCNH2 (0.47) | ALDH1A1KCNH2ALOX15MTNR1AMTNR1B | |
| SCHEMBL5657188 | 0.79 | ADAM17 (0.44) | PKM | |
| SCHEMBL6414957 | 0.78 | ADAM17 (0.44) | — | |
| SCHEMBL5661150 | 0.78 | ADAM17 (0.43) | ALDH1A1KDM4EKMT2AMEN1RAB9A | |
| SCHEMBL6408312 | 0.78 | ADAM17 (0.43) | — | |
| SCHEMBL896992 | 0.77 | ALDH1A1 (0.53) | ALDH1A1ALOX15MTNR1AMTNR1BRAB9A | |
| SCHEMBL144171 | 0.76 | THRB (0.61) | ALDH1A1ALOX15MTNR1AMTNR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179911-B2 | coupling a silyl ester of (3S)-2,2-dimethyl-tetrahydro-2H-1,4-thiazine-3-carboxylic acid with 6,4-[4-(chlorosulfonyl)phenoxy]-2-butynyl acetate, hydrolyzing the silyl ester | WYETH (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179911-B2 | coupling a silyl ester of (3S)-2,2-dimethyl-tetrahydro-2H-1,4-thiazine-3-carboxylic acid with 6,4-[4-(chlorosulfonyl)phenoxy]-2-butynyl acetate, hydrolyzing the silyl ester | WYETH (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179911-B2 | coupling a silyl ester of (3S)-2,2-dimethyl-tetrahydro-2H-1,4-thiazine-3-carboxylic acid with 6,4-[4-(chlorosulfonyl)phenoxy]-2-butynyl acetate, hydrolyzing the silyl ester | WYETH (US) | 2007-02-20 | — | — | US | disclosed |
| WO-2005123705-A1 | METHOD FOR PREPARING HYDROXAMIC ACIDS | WYETH (US) | 2005-12-29 | — | — | WO | disclosed |
| US-20050272928-A1 | Method for preparing hydroxamic acids | WYETH (US) | 2005-12-08 | — | — | US | disclosed |
| US-20050272928-A1 | Method for preparing hydroxamic acids | WYETH (US) | 2005-12-08 | — | — | US | disclosed |
| US-20050272928-A1 | Method for preparing hydroxamic acids | WYETH (US) | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272928-A1 | Method for preparing hydroxamic acids | H1-5, HDAC5, PGA5 | ALDH1A1 1059/4885KCNH2 1905/4885ALOX15 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.