Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | F9 | P00740 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658089 | 1.00 | PSEN1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5658093 | 1.00 | PSEN1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14539583 | 0.98 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5656187 | 0.95 | PSEN1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14539601 | 0.83 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4104420 | 0.83 | TAS1R3 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14534581 | 0.82 | TAS1R3 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12683535 | 0.81 | TAS1R3 (0.47) | TAS1R3TAS1R1ALDH1A1HRH3HTT | |
| SCHEMBL12894241 | 0.81 | TAS1R3 (0.47) | TAS1R3TAS1R1ALDH1A1HRH3HTT | |
| SCHEMBL27016744 | 0.81 | TAS1R3 (0.47) | TAS1R3TAS1R1ALDH1A1HRH3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7214813-B2 | Preparation of chiral cyclic amino acids and derivatives | THE PENN STATE RESEARCH FOUNDATION (US) | 2007-05-08 | — | — | US | disclosed |
| US-20040242889-A1 | Preparation of chiral cyclic amino acids and derivatives | THE PENN STATE RESEARCH FOUNDATION | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242889-A1 | Preparation of chiral cyclic amino acids and derivatives | AADAT, PAM, BCAT2 | PSEN1 3886/4885PSEN2 4080/4885APH1B 1360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.