Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.73 |
| ▸ | NAMPT | P43490 | 4/20 | 0.70 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 2/20 | 0.59 |
| ▸ | PRMT3 | O60678 | 8/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5659561 | 0.95 | NAMPT (0.70) | IMPDH2NAMPTTRPV1ROCK2MTOR | |
| SCHEMBL5658881 | 0.87 | IMPDH2 (0.70) | IMPDH2NAMPTTRPV1PRMT3 | |
| SCHEMBL20353462 | 0.85 | IMPDH2 (0.78) | IMPDH2NAMPTTRPV1ROCK2PRMT3 | |
| SCHEMBL2162998 | 0.84 | IMPDH2 (1.00) | IMPDH2NAMPTROCK2PRMT3 | |
| SCHEMBL11614113 | 0.83 | NAMPT (1.00) | NAMPTMTOR | |
| SCHEMBL15574842 | 0.80 | NAMPT (0.79) | NAMPTMTOR | |
| SCHEMBL29258285 | 0.79 | NAMPT (0.85) | NAMPTMTOR | |
| SCHEMBL5448507 | 0.79 | PRMT3 (0.64) | NAMPTTRPV1MTORPRMT3 | |
| SCHEMBL5445973 | 0.79 | ROCK2 (0.61) | NAMPTTRPV1ROCK2MTORPRMT3 | |
| SCHEMBL5658779 | 0.79 | TRPV1 (0.77) | NAMPTTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285563-B2 | Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | ARRB1, OPRL1, CNR1 | IMPDH2 3396/4885NAMPT 1466/4885TRPV1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.