Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5880701 | 0.79 | P2RX7 (0.42) | ALDH1A1GRM5PARP1 | |
| SCHEMBL6176668 | 0.76 | CCR1 (0.33) | — | |
| SCHEMBL27789848 | 0.75 | CLK1 (0.37) | CLK1ALDH1A1HPGDGRM5PARP1 | |
| SCHEMBL27854835 | 0.73 | ALDH1A1 (0.37) | CLK1ALDH1A1HPGDGRM5 | |
| SCHEMBL6180693 | 0.72 | MAPT (0.43) | ALDH1A1HPGDGRM5 | |
| SCHEMBL27656529 | 0.72 | HTR1A (0.37) | CLK1ALDH1A1HPGDGRM5 | |
| SCHEMBL12987971 | 0.72 | ALDH1A1 (0.39) | CLK1ALDH1A1HPGDGRM5 | |
| SCHEMBL249335 | 0.70 | KMT2A (0.42) | ALDH1A1 | |
| SCHEMBL2781511 | 0.70 | NCF1 (0.50) | ALDH1A1 | |
| SCHEMBL41446 | 0.70 | ALDH1A1 (0.38) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1671969-A2 | Thiazolyl inhibitors of tec family tyrosine kinases | Bristol-Myers Squibb Company (US) | 2006-06-21 | — | — | EP | disclosed |
| US-7037926-B2 | Thiazolyl inhibitors of Tec family tyrosine kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| EP-1347971-B1 | THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | disclosed |
| US-20060030598-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | BARRISH JOEL C | 2006-02-09 | — | — | US | disclosed |
| US-6958336-B2 | Thiazolyl inhibitors of Tec family tyrosine kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-25 | — | — | US | disclosed |
| US-6956045-B2 | Thiazolyl inhibitors of Tec family tyrosine kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-18 | — | — | US | disclosed |
| US-6953795-B2 | Thiazolyl inhibitors of Tec family tyrosine kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-11 | — | — | US | disclosed |
| US-20040110752-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | BARRISH JOEL C (US) | 2004-06-10 | — | — | US | disclosed |
| US-20040077695-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | BARRISH JO I C (US) | 2004-04-22 | — | — | US | disclosed |
| US-20040067990-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | BARRISH JOEL C (US) | 2004-04-08 | — | — | US | disclosed |
| US-20040067989-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | BARRISH JOEL C (US) | 2004-04-08 | — | — | US | disclosed |
| US-6706717-B2 | ANTICANCER AGENTS; IMMUNOLOGY DISEASES; ANTIALLERGENS; ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2004-03-16 | — | — | US | disclosed |
| EP-1347971-A1 | THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES | Bristol-Myers Squibb Company (US) | 2003-10-01 | — | — | EP | disclosed |
| US-20030069238-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | BRISTOL-MYERS SQUIBB COMPANY | 2003-04-10 | — | — | US | disclosed |
| WO-2002050071-A1 | THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077695-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | TEC, LCK, LTK | CLK1 975/4885ALDH1A1 2945/4885HPGD 3310/4885 |
| US-20040067990-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | TEC, LCK, LTK | CLK1 975/4885ALDH1A1 2945/4885HPGD 3310/4885 |
| US-20040067989-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | TEC, LCK, LTK | CLK1 975/4885ALDH1A1 2945/4885HPGD 3310/4885 |
| US-20030069238-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | TEC, LCK, LTK | CLK1 975/4885ALDH1A1 2945/4885HPGD 3310/4885 |
| US-20060030598-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | TEC, LCK, LTK | CLK1 975/4885ALDH1A1 2945/4885HPGD 3310/4885 |
| US-20040110752-A1 | Thiazolyl inhibitors of Tec family tyrosine kinases | TEC, LCK, LTK | CLK1 975/4885ALDH1A1 2945/4885HPGD 3310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.