Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 12/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD5 | P21918 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL29165350 | 0.98 | HTR1A (0.49) | HTR1AMAOAMAOBHTR7HPGD | |
| SCHEMBL9378395 | 0.85 | POLB (0.59) | MAOAMAOBDRD2DRD3DRD4 | |
| SCHEMBL28963619 | 0.79 | MAOA (0.42) | HTR1AMAOAMAOBHTR7HPGD | |
| SCHEMBL7168528 | 0.78 | HTR2A (0.50) | HTR1AMAOAMAOBHTR7DRD2 | |
| SCHEMBL5394439 | 0.77 | HTR7 (0.53) | HTR1AHTR7HPGDDRD2DRD5 | |
| SCHEMBL2954869 | 0.77 | HTR7 (0.53) | HTR1AHTR7HPGDDRD2DRD5 | |
| SCHEMBL30382092 | 0.77 | HTR7 (0.53) | HTR1AHTR7HPGDDRD2DRD5 | |
| SCHEMBL5113192 | 0.77 | HTR7 (0.53) | HTR1AHTR7HPGDDRD2DRD5 | |
| SCHEMBL28279911 | 0.77 | HTR7 (0.53) | HTR1AHTR7HPGDDRD2DRD5 | |
| SCHEMBL27451951 | 0.77 | HTR7 (0.53) | HTR1AHTR7HPGDDRD2DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117342995-A | Chiral 3-quaternary carbon propargyl oxindole compound and asymmetric preparation method thereof | 安徽大学 | 2024-01-05 | — | — | CN | claimed |
| CN-117342995-A | Chiral 3-quaternary carbon propargyl oxindole compound and asymmetric preparation method thereof | 安徽大学 | 2024-01-05 | — | — | CN | disclosed |
| CN-117342995-A | Chiral 3-quaternary carbon propargyl oxindole compound and asymmetric preparation method thereof | 安徽大学 | 2024-01-05 | — | — | CN | disclosed |
| US-7250442-B2 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2007-07-31 | — | — | US | disclosed |
| US-20050054712-A1 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2005-03-10 | — | — | US | disclosed |
| EP-0320992-B1 | Triazolodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-07-27 | — | — | EP | disclosed |
| US-4959361-A | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists | HOFFMANN-LA ROCHE INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0320992-A2 | Triazolodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054712-A1 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | NR3C2, NR5A1, NR5A2 | HTR1A 963/4885MAOA 3697/4885MAOB 3694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.